SED/HYP/THC- 17E

Question 1

List the symptoms of benzodiazepine withdrawal

Answer 1

• dysphoria
• intolerance to bright lights
• nausea
• muscle twitching
• autonomic hyperactivity
• disrupted sleep

Question 2

What happens to pupils in benzodiazepine withdrawal?

Answer 2

-THERE ARE NO CHARACTERISTIC PUPILS FOR BENZO WITHDRAWAL

Question 3

What is the drug used for reversal of benzo intoxication?

Answer 3

-FLUMAZENIL

Question 4

Symptoms of cannabis intoxication

Answer 4

• dry mouth
• conjunctival injection
• increased appetite
• tachycardia
• impaired judgement

Question 5

Most commonly used illicit drug in the US

Answer 5

-Marijuana

Question 6

2 main cannabinoids in marijuana

Answer 6

• THC (psychoactive)

- Cannabidiol (medical)

Question 7

THC properties

Answer 7

• crosses BBB and placenta
• acts on CB1 (central), CB2 (peripheral) receptors
• highly lipophilic therefore accumulates in fat tissues

Question 8

What regulates the endocannabinoid system?

Answer 8

• ANANDAMIDE
• neurons volume control system
• dials down neuron activity to change neurotransmitter release
• THC does the same thing but is MUCH TOO STRONG (Sledge hammer)

Question 9

THC effects on memory

Answer 9

• suppresses hippocampal neuron activity leading to neuron loss
• smaller hippocampal volumes compared to non-users

Question 10

Average THC content in recent Marijuana strains

Answer 10

-17-18%

Question 11

What is the connection between THC and psychotic symptoms?

Answer 11

-cannabis causes persistence of psychotic symptoms and anticipates development of psychotic disorders

Question 12

Effect of marijuana on driving

Answer 12

• doubled risk of collision

- impairment of attention, working memory, reaction time, coordination, visual perception

Question 13

Current thought on medical marijuana

Answer 13

• no data on efficacy, safety, or tolerability in pediatric conditions
• known harmful effects on the developing brain