Psychosis 2- 12B Flashcards
What is the black box warning for FGAs and SGAs
- increased mortality in elderly patients with dementia/NCD
- Haldol highest risk
- Seroquel least risky
Low potency FGA’s have
- weaker DA blockade
- but are more sedating
Thioridizine has high risk of
- cardiovascular side effects
- has additional black box warning
- AND highest risk of pigmentary retinopathy
SGA’s with highest risk of development of metabolic syndrome
-olanzapine and clozapine
The most effective SGA
CLOZAPINE
SGA’s with lower risk of metabolic syndrome
Aripiprazole, Lurasidone, Ziprasidone
SGA’s with lower risk of QTc prolongation
-Latuda, Abilify, cariprazine
SGA’s with lower risk of EPS
-Seroquel, Clozaril
SGA’s and neuroleptic malignant syndrome
-NO DIFFERENCES NOTED
Important side effect of Fanapt (Iloperidone)
orthostatic hypotension
Antipsychotic developed for treatment of psychosis in Parkinson’s Disease
Pimavanserin (Nuplazid)
-peripheral edema side effect
Latest safety alert for Abilify
-compulsive, uncontrollable urges to gamble, binge eat, shop, and have sex
Potentially lethal side effect of Clozaril with high mortality rate
-cardiomyopathy, myocarditis
Greatest risk of death associated with Clozaril
- cardiomyopathy, myocarditis
- agranulocytosis
- PE/DVT
Name risks for developing TD
- Elderly
- Female
- diabetes
- mood disorders
