MOC Exam#8 Flashcards

1
Q

ECT is safe in the presence of which cardiac illnesses

A
  • ischemic heart disease
  • heart faillure
  • heart transplants
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2
Q

ECT is a strong contraindication in the setting of which heart diseases

A
  • acute myocardial infarction

- malignant tachyarrhythmias

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3
Q

Which psychiatric disorder has the highest all cause mortality rate?

A

Anorexia nervosa

  • medical comorbidities: cardiac arrhythmia, electrolyte imbalances
  • suicide
  • all-cause mortality rate of 5.9
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4
Q

Compare the all-cause mortality rates of :

  • anorexia nervosa
  • schizophrenia
  • major depressive disorder
  • bipolar disorder
  • bulimia nervosa
A
  • anorexia nervosa: 5.9
  • schizophrenia: 2.5
  • major depressive disorder: 1.6
  • bipolar disorder: 2.2
  • bulimia nervosa: 1.9
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5
Q

The best strategies for preventing relapse of MDD after successful course of ECT:

A
  • maintenance ECT

- Venlafaxine + Lithium

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6
Q

Anti-dopaminergic medications (SGA’s) should be continued when catatonia is identified. TRUE or FALSE

A

FALSE

-stop antipsychotics and give LORAZEPAM

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7
Q

CSF findings in vCJD

A
  • elevated tau protein levels

- lower levels of 14-3-3 protein

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8
Q

Effects of in utero exposure to cannabis, alcohol, nicotine

A
  • increased prevalence of ADHD and aggression in children
  • cannabis transfers into breast milk in very high concentrations
  • compared to alcohol concentration in breast milk which is low
  • nicotine transfers at a higher rate in breast milk than transplacentally
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9
Q

Potential adverse effects of Valproic acid

A
  • hepatic dysfunction
  • hemorrhagic pancreatitis
  • teratogenic effects
  • polycystic ovarian syndrome
  • thrombocytopenia (especially in the elderly)
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10
Q

Lithium and hypernatremia

A
  • most common drug cause of hypernatremia

- most common cause of nephrogenic diabetes insipidus

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11
Q

Risperidone is metabolized only by CYP

A

2D6

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12
Q

Fluoxetine inhibits which of the CYP

A

1A2, 2C, 2D6, 3A4

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13
Q

Which chromosome is involved in the development of frontotemporal neurocognitive disorder?

A
Chromosome 17 (FTP-17)
-neuronal and glial inclusions that stain positive for MAP-T
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14
Q

Chromosomal involvement of Alzheimer’s Disease

A
  • Chromosome 19 (for early onset)
  • Chr 1 (presenillin 2)
  • Chr 14 (presenillin 1)
  • Chr 21 (APP)
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15
Q

Bipolar disorder is a consistent risk factor for postpartum psychosis. TRUE or FALSE

A

TRUE

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16
Q

Factor that predicts worsening mood/depression following bariatric surgery

A

-post-operative weight gain

best factor predicting worsening mood symptoms in bariatric surgery pt

17
Q

What are Lewy Bodies made of?

A
  • alpha synuclein

- ubiquitin

18
Q

All patients with neurocognitive impairment should be screened for

A

DRIVING SAFETY

19
Q

Korsakoff’s syndrome

A
  • thiamine deficiency in the setting of malnourishment
  • potentially reversible with IM or IV injections of 100 mg thiamine
  • associated with ophthalmlplegia, cerebellar ataxia, confusion (Wernicke’s encephalopathy)
20
Q

What is clorazepate?

A

long acting benzodiazepine

21
Q

What is CAM?

A
  • the Confusion Assessment Method

- 4-item screening questionnaire for delirium

22
Q

Strategies for pharmacologic management of severe OCD

A
  • SSRI
  • SSRI + atypical (response 40-50%)
  • SSRI + CBT
  • switch SSRI
  • SSRI + Clomipramine
  • Deep brain stimulation
23
Q

Most appropriate test for assessing delirium

A

Digit span- assess for attention deficits

24
Q

Delirium is most highly associated with which neurotransmitter

A

Acetylcholine

25
Q

Best treatment for tardive dyskinesia

A

reduction of dose or discontinuation of antipsychotic medications

  • BENZTROPINE IS NOT EFFECTIVE FOR TARDIVE DYSKINESIA
  • ECT treatment for TD has response rate of 39%
26
Q

Contraindications for Galantamine use

A
  • severe renal and hepatic impairment

- metabolic disorders of galactose metabolism