Psychosis1- 12A Flashcards
List the time criteria for
Brief Psychotic Disorder
Schizophreniform Disorder
Schizophrenia
- at most 1 month
- between 1-6 months
- greater than 6 months
Name the good prognostic features for schizophreniform disorder
- onset of psychotic symptoms within 4 weeks of noticed behavioral change
- confusion or perplexity at the peak of episode
- good premorbid social and occupational functioning
- absence of negative symptoms
The criteria for brief psychotic disorder are similar to those of schizophrenia with the exception of time course and _____?
-negative symptoms are not required to make diagnosis
Lifetime prevalence of schizophrenia
1%
Peak age of onset of schizophrenia
15-25 y for males
25-35y for females
Positive sx schizophrenia mapped to which DA pathway
mesolimbic
Mechanism of action of all SGAs
- antagonism or inverse agonism at 5HT2A
- antagonism at D2
Typical findings on structural imaging of brains in pts with schizophrenia
- decreased brain volume leading to
- enlarged ventricles
Typical findings of functional imaging of brains in pts with schizophrenia
-deficits in the dorsolateral prefrontal ctx and anterior cingulate ctx
Name neurophysiologic dysfunction in schizophrenia
-abnormal eye tracking/visual pursuit
Inheritance of schizophrenia
1% general pop
47% monozygotic twins
17% dizygotic twins
10-15% first degree relatives
Environmental risk factors for schizophrenia
- birth in winter
- influenza during pregancy
- maternal major stressor during pregnancy
- obstetric complications
- advanced paternal age
What is typical of premorbid function before onset of schizophrenia
-normal functioning and development
Risk factors for suicide in patients with schizophrenia
- Young age
- Higher IQ
- Higher SES
- Good premorbid functions
- Higher aspirations, goals
Name the phases and the timing of schizophrenia management as outlined by APA
0-2 months acute (onset to baseline)
2-6 months stabilization (baseline to remission)
greater than 6 months stabile (working on life goals)
