(Section B: Immunology) Lecture 09: Introduction Flashcards

1
Q

Innate vs. Adaptive

A
  • Innate: Stays same, doesn’t learn
  • Adaptive: Reacts faster and larger second time
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2
Q

Purpose of Immune Systems

A
  1. “Defense against Invader”
  2. “Self-nonself discrimination”
  3. “Detection of Danger/Damage”
  4. Achieve peace and harmony w/ our enemies”
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3
Q

Components of the Immune System

A
  1. Barriers
  2. Cells
  3. Soluble Molecules (Humoral)
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4
Q

What is the analogy used for components of the immune system?

A
  1. Barriers, “Wall”
  2. Soldiers, “Soldiers”
  3. Soluble Molecules (Humoral), “Weapons”
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5
Q

What types of barriers are there?

A
  1. Mechanical
  2. Chemical
  3. Microbial
  4. Nutritional
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6
Q

What the main cells in mechanical barriers?

A

Epithelial cells

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7
Q

Describe:

Epithelial cells

A
  • Lines the surfaces of various tracts (stomach, throat, skin etc.)
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8
Q

How are epithelial cells joined? Why?

A

Prevent pathogens from entering

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9
Q

How do epithelial cells work as mechanical barriers?

A
  1. Regeneration
  2. Desquamation (shedding)
  3. Secretions (mucus etc.)
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10
Q

What is the first line of defense?

A

Skin

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11
Q

What are skin cells known as?

A

Keratinocytes

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12
Q

What do keratinocytes form?

A

The corneal layer (keratin “shield”)

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13
Q

What are goblet cells and where are they found?

A

Goblet cells makes mucus and secretions
Found in the lungs

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14
Q

What is responsible for moving things out (coughing) in lungs?

A

Cilia

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15
Q

What do chemical barriers include?

A

Includes enzymes

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16
Q

What are forms of chemical barriers?

A
  1. Lysozymes
  2. Antimicrobial peptides
  3. Fatty acids
17
Q

What are lysosymes secreted by?

A

Epithelial cells

18
Q

What are the functions of lysosymes?

A

The digest bacterial cell walls (peptidoglycan)

19
Q

Antimicrobial peptides

A

Short positively charged peptides

20
Q

Give an example of an antimicrobial peptide

A

Cathelicidin

21
Q

How many different antimicrobial peptides are characterized in humans?

A

21 different types

22
Q

What fatty acids have antimicrobial properties?

A

Saturated and Unsaturated

23
Q

How much microorganisms are in our body?

A

38 trillion

24
Q

What are antimicrobial peptides and fatty acids known as?

A

Defensins

25
Q

What do microbes need in order to function?

A

Metals (iron etc.)

26
Q

How do we inhibit microbial growth nutrition wise?

A

Sequestering metals

27
Q

What is iron pumped out of intracellular compartments by?

A

NRAMP1

28
Q

What is iron complexed with in the body?

A

Heme, which is bound by hemoglobulin

29
Q

What is free heme bound by?

A

Hemopexin (HPX)

30
Q

What is free hemoglobin bound by?

A

Haptoglobin (HP)

31
Q

How will bacteria try to collect iron?

A

By secreting sidephore molecules