(Section A: Virology) Lecture 01: Introduction to Virology Flashcards

1
Q

What are the 3 levels of defense mechanisms?

A
  1. Intrinsic (skin, hair etc.)
  2. Innate Immunity
  3. Acquired Immunity
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2
Q

Are all viruses bad?

A

No, some viruses can form symbiogenic relationships with other organisms

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3
Q

List:

What is necessary for a virus to survive?

A
  1. Package genome inside particle
  2. Use particle to transfer genome from host to host
  3. Genome contains info to initiate/complete viral infectious cycle
  4. Genome establishes in host, ensures long-term survival
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4
Q

Dr. Dikeakos emphasizes:

What is key for viruses?

A

Genome

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5
Q

Viruses are…

A

Obligate, molecular parasites
* Means they are useless on their own

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6
Q

Do viruses grow?

A

No, they replicate

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7
Q

Do viruses always cause diseases?

A

No, it’s about a balance
* They occasionally cause sickness
* They occasionally stay dormant

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8
Q

How long have viruses existed? How did we find this out?

A

Over 250 million years
* Using molecular clock sequencing technology

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9
Q

What experiment is famous for giving the first definition of a virus?

A

Ivanovsky’s & Beijerinck’s Tobacco Mosaic Virus (TMV) Experiment

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10
Q

Describe:

The Tobacco Mosaic Virus Experiment

A
  • Leaf was crushed
  • Crushed leaf was filtered
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11
Q

What was the result from TBV Experiment?

A
  1. Crushed leaf did not infect others with disease
  2. Filtrate caused disease

Virus is filtrable

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12
Q

True or False:

Viruses can replicate on their own

A

False, they need a host in order to replicate

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13
Q

Describe:

The size of viruses

A

~1/1000 the size of E. coli
* Can be filtered through 0.2 micron filter

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14
Q

Are all viruses small?

A

Not exactly
* Mimiviruses can be seen under a light microscope

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15
Q

Define:

Virus

A

Very small, infectious, obligate intracellular parasite that needs cellular host

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