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HEMATOLOGY 2 > SECONDARY HEMOSTASIS > Flashcards

SECONDARY HEMOSTASIS Flashcards

1
Q

Primary site of coagulation factor production.

A

Liver (except Factors III and IV).

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2
Q

Major production site of Factor VIII.

A

Liver (vWF portion made by megakaryocytes and endothelial cells).

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3
Q

Coagulation factors increased in liver disease.

A

Factors I and VIII.

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4
Q

Coagulation factor with the shortest half-life.

A

Factor VII (6 hours).

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5
Q

Effect of acute liver dysfunction on Factor VII.

A

Levels of Factor VII reduced early; PT is a good test for liver function.

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6
Q

Transmission pattern for coagulation factor deficiencies.

A

Most are autosomal recessive; Factor VIII and IX are X-linked recessive.

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7
Q

Other name for Factor I.

A

Fibrinogen.

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8
Q

Most concentrated plasma procoagulant.

A

Fibrinogen.

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9
Q

Fibrinogen molecular weight.

A

340,000 Daltons.

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10
Q

Fibrinogen half-life.

A

100 to 150 hours.

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11
Q

Fibrinogen plasma concentration.

A

200 to 400 mg/dL.

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12
Q

Effect of fibrinogen <100 mg/dL on PT and aPTT.

A

Both PT and aPTT prolonged.

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13
Q

Role of fibrinogen in platelet aggregation.

A

Links activated platelets through GP IIb/IIIa receptor.

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14
Q

Storage and release of fibrinogen.

A

Stored and released by platelet alpha granules.

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15
Q

Fibrinogen level increase in elderly.

A

Increases 10 mg/dL per decade (1 mg/dL per year).

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16
Q

Other name for Factor II.

A

Prothrombin.

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17
Q

Prothrombin molecular weight.

A

71,600 Daltons.

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18
Q

Prothrombin half-life.

A

60 hours.

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19
Q

Prothrombin plasma concentration.

A

10 mg/dL.

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20
Q

Prothrombin is converted to?

A

Thrombin (Factor IIa).

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21
Q

Conversion of prothrombin to thrombin?

A

Activated by factor X-Va.

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22
Q

Other names for Factor III.

A

Tissue Factor, Tissue Thromboplastin, Thrombokinase.

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23
Q

Factor III molecular weight.

A

44,000 Daltons.

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24
Q

Factor III half-life.

A

Insoluble.

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25
Factor III plasma concentration.
None.
26
Which factor is Calcium ions?
Factor IV.
27
Factor IV molecular weight.
40 Daltons.
28
Factor IV plasma concentration.
8 to 10 mg/dL.
29
Other names for Factor V.
Proaccelerin, Labile Factor, Thrombogen.
30
Factor V molecular weight.
330,000 Daltons.
31
Factor V half-life.
24 hours.
32
Factor V plasma concentration.
1 mg/dL.
33
What is Factor V Leiden?
Mutant factor V, not inactivated by Protein C-S complex, leads to excessive clot formation.
34
Condition associated with Factor V deficiency.
Owren's disease (parahemophilia).
35
Factor VII other names.
Proconvertin, Stable Factor.
36
Factor VII molecular weight.
50,000 Daltons.
37
Factor VII half-life.
6 hours.
38
Factor VII plasma concentration.
0.05 mg/dL.
39
First coagulation factor affected by warfarin therapy.
Factor VII.
40
Factor VII lifespan.
Shortest lifespan.
41
Factor VIII other names.
Antihemophilic Factor A (AHF-A), Antihemophilic globulin (AHG).
42
Factor VIII molecular weight.
330,000 Daltons.
43
Factor VIII half-life.
12 hours.
44
Factor VIII plasma concentration.
0.01 mg/dL.
45
Condition associated with Factor VIII deficiency.
Hemophilia A or Classic Hemophilia.
46
Factor VIII circulates in the blood bound to.
vWF (von Willebrand factor), forming the Factor VIII complex.
47
Procoagulant portion of Factor VIII complex.
Factor VIII, Factor VIIIC, Factor VIII:C; measured by standard Factor VIII assays and APTT, decreased in Hemophilia A.
48
Factor VIII: Ag refers to.
Antigenic properties of Factor VIII; measured by immunoassays.
49
Factor VIIIR:RCo refers to.
Portion of Factor VIII responsible for platelet aggregation in the presence of ristocetin; termed ristocetin cofactor.
50
Factor VIII:vWF role.
Required for normal platelet adhesion.
51
vWF:Ag refers to.
Antigenic portion of von Willebrand factor; previously termed Factor VIII related antigen (VIIIR:Ag), measured by immunoassays.
52
vWF molecular weight range
600,000 to 20,000,000 Daltons (largest in plasma).
53
vWF half-life
24 hours.
54
vWF mean plasma concentration
1 mg/dL.
55
vWF function
Binds platelets to exposed subendothelial collagen during platelet adhesion.
56
Primary platelet surface receptor for vWF
GP Ib/IX/V.
57
Factor IX other name
Christmas Factor, Antihemophilic Factor B (AHF-B), Plasma Thromboplastin Component (PTC).
58
Factor IX molecular weight
57,000 Daltons.
59
Factor IX half-life
24 hours.
60
Factor IX mean plasma concentration
0.3 mg/dL.
61
Factor IX deficiency causes
Hemophilia B.
62
Factor X other name
Stuart-Prower Factor.
63
X Stuart-Prower Factor molecular weight
58,800 Daltons.
64
X Stuart-Prower Factor half-life
48 to 52 hours.
65
X Stuart-Prower Factor mean plasma concentration
1 mg/dL.
66
Factor XI other name
Antihemophilic Factor C, Plasma Thromboplastin Antecedent (PTA).
67
XI Antihemophilic Factor C molecular weight
143,000 Daltons.
68
XI Antihemophilic Factor C half-life
48 to 84 hours.
69
XI Antihemophilic Factor C mean plasma concentration
0.5 mg/dL.
70
XI Antihemophilic Factor C deficiency causes
Hemophilia C or Rosenthal Syndrome.
71
Hemophilia C occurrence
>50% of cases show bleeding tendency.
72
Hemophilia C genetic associations
Seen in Ashkenazi Jews and Niemann-Pick disease.
73
Factor XII other name
Hageman Factor, Glass Factor, Contact Factor.
74
XII Hageman Factor molecular weight
84,000 Daltons.
75
XII Hageman Factor half-life
48 to 70 hours.
76
XII Hageman Factor mean plasma concentration
3 mg/dL.
77
XII Hageman Factor bleeding tendency
No bleeding tendency, thrombocytic tendency.
78
Factor XIII other name
Fibrin Stabilizing Factor, Fibrinase, Laki-Lorand Factor.
79
XIII Fibrin Stabilizing Factor molecular weight
320,000 Daltons.
80
XIII Fibrin Stabilizing Factor half-life
150 hours.
81
XIII Fibrin Stabilizing Factor mean plasma concentration
2 mg/dL.
82
XIII Fibrin Stabilizing Factor detection test
Clot stability with 5M urea (Duckert's test).
83
XIII Fibrin Stabilizing Factor deficiency result
Soluble clot in Duckert's test, indicating FXIII deficiency.
84
XIII Fibrin Stabilizing Factor presence result
Insoluble clot in Duckert's test, indicating FXIII is present.
85
Prekallikrein other name
Fletcher Factor.
86
PK Prekallikrein molecular weight
85,000 Daltons.
87
PK Prekallikrein half-life
35 hours.
88
PK Prekallikrein mean plasma concentration
35 to 50 μg/mL.
89
HMWK High-molecular-weight Kininogen other names
Reid Factor, Williams Factor, Fitzgerald Factor, Flaujeac Factor.
90
HMWK High-molecular-weight Kininogen molecular weight
120,000 Daltons.
91
HMWK High-molecular-weight Kininogen half-life
156 hours.
92
HMWK High-molecular-weight Kininogen mean plasma concentration
5 mg/dL.
93
Platelet factor 3 (PF-3)
Platelet phospholipids, particularly phosphatidylserine, considered coagulation factors.
94
Coagulation factors that are enzymes and circulate as zymogens
Prothrombin (II), VII, IX, X, XI, XII, Prekallikrein, XIII.
95
Serine protease coagulation factors
Prothrombin (II), VII, IX, X, XI, XII, Prekallikrein.
96
Coagulation factors that function as cofactors
Tissue factor (III), Factor V, Factor VIII, HMWK.

HEMATOLOGY 2 (15 decks)

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