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HEMATOLOGY 2 > SECONDARY HEMOSTASIS > Flashcards

SECONDARY HEMOSTASIS Flashcards

1
Q

Primary site of coagulation factor production.

A

Liver (except Factors III and IV).

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2
Q

Major production site of Factor VIII.

A

Liver (vWF portion made by megakaryocytes and endothelial cells).

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3
Q

Coagulation factors increased in liver disease.

A

Factors I and VIII.

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4
Q

Coagulation factor with the shortest half-life.

A

Factor VII (6 hours).

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5
Q

Effect of acute liver dysfunction on Factor VII.

A

Levels of Factor VII reduced early; PT is a good test for liver function.

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6
Q

Transmission pattern for coagulation factor deficiencies.

A

Most are autosomal recessive; Factor VIII and IX are X-linked recessive.

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7
Q

Other name for Factor I.

A

Fibrinogen.

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8
Q

Most concentrated plasma procoagulant.

A

Fibrinogen.

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9
Q

Fibrinogen molecular weight.

A

340,000 Daltons.

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10
Q

Fibrinogen half-life.

A

100 to 150 hours.

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11
Q

Fibrinogen plasma concentration.

A

200 to 400 mg/dL.

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12
Q

Effect of fibrinogen <100 mg/dL on PT and aPTT.

A

Both PT and aPTT prolonged.

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13
Q

Role of fibrinogen in platelet aggregation.

A

Links activated platelets through GP IIb/IIIa receptor.

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14
Q

Storage and release of fibrinogen.

A

Stored and released by platelet alpha granules.

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15
Q

Fibrinogen level increase in elderly.

A

Increases 10 mg/dL per decade (1 mg/dL per year).

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16
Q

Other name for Factor II.

A

Prothrombin.

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17
Q

Prothrombin molecular weight.

A

71,600 Daltons.

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18
Q

Prothrombin half-life.

A

60 hours.

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19
Q

Prothrombin plasma concentration.

A

10 mg/dL.

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20
Q

Prothrombin is converted to?

A

Thrombin (Factor IIa).

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21
Q

Conversion of prothrombin to thrombin?

A

Activated by factor X-Va.

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22
Q

Other names for Factor III.

A

Tissue Factor, Tissue Thromboplastin, Thrombokinase.

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23
Q

Factor III molecular weight.

A

44,000 Daltons.

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24
Q

Factor III half-life.

A

Insoluble.

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25
Q

Factor III plasma concentration.

A

None.

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26
Q

Which factor is Calcium ions?

A

Factor IV.

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27
Q

Factor IV molecular weight.

A

40 Daltons.

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28
Q

Factor IV plasma concentration.

A

8 to 10 mg/dL.

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29
Q

Other names for Factor V.

A

Proaccelerin, Labile Factor, Thrombogen.

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30
Q

Factor V molecular weight.

A

330,000 Daltons.

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31
Q

Factor V half-life.

A

24 hours.

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32
Q

Factor V plasma concentration.

A

1 mg/dL.

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33
Q

What is Factor V Leiden?

A

Mutant factor V, not inactivated by Protein C-S complex, leads to excessive clot formation.

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34
Q

Condition associated with Factor V deficiency.

A

Owren’s disease (parahemophilia).

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35
Q

Factor VII other names.

A

Proconvertin, Stable Factor.

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36
Q

Factor VII molecular weight.

A

50,000 Daltons.

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37
Q

Factor VII half-life.

A

6 hours.

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38
Q

Factor VII plasma concentration.

A

0.05 mg/dL.

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39
Q

First coagulation factor affected by warfarin therapy.

A

Factor VII.

40
Q

Factor VII lifespan.

A

Shortest lifespan.

41
Q

Factor VIII other names.

A

Antihemophilic Factor A (AHF-A), Antihemophilic globulin (AHG).

42
Q

Factor VIII molecular weight.

A

330,000 Daltons.

43
Q

Factor VIII half-life.

A

12 hours.

44
Q

Factor VIII plasma concentration.

A

0.01 mg/dL.

45
Q

Condition associated with Factor VIII deficiency.

A

Hemophilia A or Classic Hemophilia.

46
Q

Factor VIII circulates in the blood bound to.

A

vWF (von Willebrand factor), forming the Factor VIII complex.

47
Q

Procoagulant portion of Factor VIII complex.

A

Factor VIII, Factor VIIIC, Factor VIII:C; measured by standard Factor VIII assays and APTT, decreased in Hemophilia A.

48
Q

Factor VIII: Ag refers to.

A

Antigenic properties of Factor VIII; measured by immunoassays.

49
Q

Factor VIIIR:RCo refers to.

A

Portion of Factor VIII responsible for platelet aggregation in the presence of ristocetin; termed ristocetin cofactor.

50
Q

Factor VIII:vWF role.

A

Required for normal platelet adhesion.

51
Q

vWF:Ag refers to.

A

Antigenic portion of von Willebrand factor; previously termed Factor VIII related antigen (VIIIR:Ag), measured by immunoassays.

52
Q

vWF molecular weight range

A

600,000 to 20,000,000 Daltons (largest in plasma).

53
Q

vWF half-life

A

24 hours.

54
Q

vWF mean plasma concentration

A

1 mg/dL.

55
Q

vWF function

A

Binds platelets to exposed subendothelial collagen during platelet adhesion.

56
Q

Primary platelet surface receptor for vWF

A

GP Ib/IX/V.

57
Q

Factor IX other name

A

Christmas Factor, Antihemophilic Factor B (AHF-B), Plasma Thromboplastin Component (PTC).

58
Q

Factor IX molecular weight

A

57,000 Daltons.

59
Q

Factor IX half-life

A

24 hours.

60
Q

Factor IX mean plasma concentration

A

0.3 mg/dL.

61
Q

Factor IX deficiency causes

A

Hemophilia B.

62
Q

Factor X other name

A

Stuart-Prower Factor.

63
Q

X Stuart-Prower Factor molecular weight

A

58,800 Daltons.

64
Q

X Stuart-Prower Factor half-life

A

48 to 52 hours.

65
Q

X Stuart-Prower Factor mean plasma concentration

A

1 mg/dL.

66
Q

Factor XI other name

A

Antihemophilic Factor C, Plasma Thromboplastin Antecedent (PTA).

67
Q

XI Antihemophilic Factor C molecular weight

A

143,000 Daltons.

68
Q

XI Antihemophilic Factor C half-life

A

48 to 84 hours.

69
Q

XI Antihemophilic Factor C mean plasma concentration

A

0.5 mg/dL.

70
Q

XI Antihemophilic Factor C deficiency causes

A

Hemophilia C or Rosenthal Syndrome.

71
Q

Hemophilia C occurrence

A

> 50% of cases show bleeding tendency.

72
Q

Hemophilia C genetic associations

A

Seen in Ashkenazi Jews and Niemann-Pick disease.

73
Q

Factor XII other name

A

Hageman Factor, Glass Factor, Contact Factor.

74
Q

XII Hageman Factor molecular weight

A

84,000 Daltons.

75
Q

XII Hageman Factor half-life

A

48 to 70 hours.

76
Q

XII Hageman Factor mean plasma concentration

A

3 mg/dL.

77
Q

XII Hageman Factor bleeding tendency

A

No bleeding tendency, thrombocytic tendency.

78
Q

Factor XIII other name

A

Fibrin Stabilizing Factor, Fibrinase, Laki-Lorand Factor.

79
Q

XIII Fibrin Stabilizing Factor molecular weight

A

320,000 Daltons.

80
Q

XIII Fibrin Stabilizing Factor half-life

A

150 hours.

81
Q

XIII Fibrin Stabilizing Factor mean plasma concentration

A

2 mg/dL.

82
Q

XIII Fibrin Stabilizing Factor detection test

A

Clot stability with 5M urea (Duckert’s test).

83
Q

XIII Fibrin Stabilizing Factor deficiency result

A

Soluble clot in Duckert’s test, indicating FXIII deficiency.

84
Q

XIII Fibrin Stabilizing Factor presence result

A

Insoluble clot in Duckert’s test, indicating FXIII is present.

85
Q

Prekallikrein other name

A

Fletcher Factor.

86
Q

PK Prekallikrein molecular weight

A

85,000 Daltons.

87
Q

PK Prekallikrein half-life

A

35 hours.

88
Q

PK Prekallikrein mean plasma concentration

A

35 to 50 μg/mL.

89
Q

HMWK High-molecular-weight Kininogen other names

A

Reid Factor, Williams Factor, Fitzgerald Factor, Flaujeac Factor.

90
Q

HMWK High-molecular-weight Kininogen molecular weight

A

120,000 Daltons.

91
Q

HMWK High-molecular-weight Kininogen half-life

A

156 hours.

92
Q

HMWK High-molecular-weight Kininogen mean plasma concentration

A

5 mg/dL.

93
Q

Platelet factor 3 (PF-3)

A

Platelet phospholipids, particularly phosphatidylserine, considered coagulation factors.

94
Q

Coagulation factors that are enzymes and circulate as zymogens

A

Prothrombin (II), VII, IX, X, XI, XII, Prekallikrein, XIII.

95
Q

Serine protease coagulation factors

A

Prothrombin (II), VII, IX, X, XI, XII, Prekallikrein.

96
Q

Coagulation factors that function as cofactors

A

Tissue factor (III), Factor V, Factor VIII, HMWK.

HEMATOLOGY 2 (15 decks)

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