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HEMATOLOGY 2 > GROUP OF CLOTTING FACTORS > Flashcards

GROUP OF CLOTTING FACTORS Flashcards

1
Q

Intrinsic coagulation factors

A

XII, XI, IX, VIII

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2
Q

Extrinsic coagulation factors

A

III, VII

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3
Q

Common coagulation pathway factors

A

I, II, V, X

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4
Q

Coagulation factors in the Fibrinogen group

A

I, V, VIII, XIII

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5
Q

Coagulation factors in the Prothrombin group

A

II, VII, IX, X

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6
Q

Coagulation factors in the Contact group

A

XII, XI, PK, HMWK

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7
Q

Group including thrombin-sensitive factors absent in serum, calcium-dependent, and vitamin K-independent

A

I, V, VIII, XIII (Fibrinogen Group)

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8
Q

Conditions increasing Fibrinogen group factors (I, V, VIII, XIII)

A

Pregnancy, Inflammation, Stress, Oral contraceptives (PISO)

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9
Q

Properties of the Prothrombin group (II, VII, IX, X)

A

Present in aged serum except Factor II; Vitamin K-dependent; Calcium-dependent; Adsorbed using barium sulfate or alum hydroxide

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10
Q

Properties of the Contact group (XII, XI, PK, HMWK)

A

Vitamin K-independent; Calcium-independent

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11
Q

PIVKA definition and role in coagulation

A

Proteins induced by vitamin K absence; Synthesized in the liver; Ineffective in coagulation; Do not participate in the coagulation process

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12
Q

Primary trigger for the extrinsic pathway

A

Tissue factor (TF) release from vascular injury

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13
Q

Primary trigger for the intrinsic pathway

A

Contact activation (exposure to negatively charged surfaces)

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14
Q

Factor that initiates the extrinsic pathway

A

VII

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15
Q

Factor that initiates the intrinsic pathway

A

XII

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16
Q

Role of TF-VIIa complex in coagulation

A

Activates Factor IX and Factor X

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17
Q

Amplification step in the intrinsic pathway

A

VIIIa enhances activation of Factor X

18
Q

Calcium (Ca²⁺) dependency in coagulation

A

Required for activation of multiple steps in all pathways

19
Q

Prothrombin activation to thrombin

A

Xa-Va complex (prothrombinase) converts prothrombin to thrombin

20
Q

Thrombin’s role in fibrin formation

A

Converts fibrinogen to soluble fibrin

21
Q

Stabilization of fibrin clot

A

Factor XIIIa cross-links fibrin to form crosslinked fibrin

22
Q

Common pathway factors

A

X, V, II (Prothrombin), I (Fibrinogen)

23
Q

Intrinsic pathway sequence

A

XII → XI → IX → VIII → X

24
Q

Extrinsic pathway sequence

A

TF → VII → X

25
Q

Function of Factor V and VIII in coagulation

A

Cofactors that enhance activation of downstream factors

26
Q

Tests used to evaluate extrinsic and intrinsic pathways

A

PT for extrinsic, aPTT for intrinsic

27
Q

Final product of the coagulation cascade

A

Crosslinked fibrin clot

28
Q

Factors activated by thrombin

A

1, 5, 8, 13

29
Q

Components of the tenase complex

A

9a, platelet factor-3 (PF-3), Calcium, 8a

30
Q

Components of the prothrombinase complex

A

10a, PF-3, Calcium, 5a

31
Q

Phases of coagulation where calcium is involved

A

All phases except the contact phase

32
Q

Solubility of stabilized fibrin clot to 5M Urea

A

Not soluble

33
Q

Two cell types required for normal physiologic coagulation

A

Tissue factor-bearing cells (extravascular) and platelets (intravascular)

34
Q

Phase of in vivo coagulation occurring on tissue factor-bearing cells

A

Initiation phase

35
Q

Percentage of total thrombin generated during the initiation phase

A

3% to 5%

36
Q

Phase of in vivo coagulation occurring on platelets

A

Propagation phase

37
Q

Percentage of total thrombin generated during the propagation phase

A

> 95%

38
Q

Primary function of TF:VIIa complex in vivo

A

Activates Factors IX and X

39
Q

Factors activated by thrombin during initiation phase

A

V, VIII, XI, and platelets

40
Q

Key complexes formed on activated platelets during propagation phase

A

IXa:VIIIa and Xa:Va

41
Q

Outcome of the thrombin burst in the propagation phase

A

Cleaves fibrinogen to fibrin

HEMATOLOGY 2 (15 decks)

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