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HEMATOLOGY 2 > Other related notes > Flashcards

Other related notes Flashcards

1
Q

Key proteins involved in platelet activation

A

G proteins (guanine nucleotide-binding proteins)

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2
Q

Function of G proteins in platelet activation

A

Stimulate eicosanoid synthesis and IP3-DAG pathways”

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3
Q

Two pathways stimulated by G proteins during platelet activation

A

Eicosanoid synthesis and IP3-DAG pathways

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4
Q

Platelet activation pathways controlled by G proteins

A

Eicosanoid synthesis and IP3-DAG

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5
Q

Eicosanoid synthesis pathway also known as

A

Prostaglandin, cyclooxygenase, or thromboxane pathway

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6
Q

Eicosanoids are derived from

A

Arachidonic acid or a similar fatty acid

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7
Q

Examples of eicosanoids

A

Prostacyclin, thromboxane

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8
Q

Receptors activated by collagen, ADP, thrombin, and epinephrine

A

Phospholipase A2

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9
Q

Phospholipase A2 releases

A

Arachidonic acid from phosphatidylinositol

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10
Q

Enzymes that act on arachidonic acid in platelet activation

A

Cyclooxygenase, peroxidase, thromboxane synthase

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11
Q

Thromboxane A2 (TXA2) function in platelet activation

A

Activates platelet, suppresses adenylate cyclase, reduces cAMP

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12
Q

Role of ionic calcium in platelet activation

A

Supports actin microfilament contraction

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13
Q

Eicosanoid pathway in endothelial cells vs platelets

A

Endothelial cells have prostacyclin synthase; platelets have thromboxane synthase

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14
Q

Eicosanoid pathway result in endothelial cells

A

Prostaglandin I2 (prostacyclin)

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15
Q

Prostacyclin function on platelets

A

Binds to IP receptor, accelerates adenylate cyclase, increases cAMP

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16
Q

Effect of prostacyclin on ionic calcium

A

Sequesters ionic calcium to the DTS

17
Q

Function of endothelial eicosanoid pathway in intact blood vessels

A

Suppresses platelet activation

18
Q

Activation of IP3-DAG pathway

A

G-protein activates phospholipase C

19
Q

Phospholipase C function in IP3-DAG pathway

A

Cleaves phosphatidylinositol 4,5-bisphosphate to form IP3 and DAG

20
Q

Function of IP3 in platelet activation

A

Promotes release of ionic calcium from DTS, activates actin microfilament contraction

21
Q

IP3 effect on phospholipase A2

A

IP3 may activate phospholipase A2

22
Q

Role of DAG in platelet activation

A

Activates phosphokinase C, triggers phosphorylation of pleckstrin

HEMATOLOGY 2 (15 decks)

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