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HEMATOLOGY 2 > Platelet activation > Flashcards

Platelet activation Flashcards

1
Q

Process initiated by blood vessel injury

A

Exposes collagen, releases VWF, releases tissue factor

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2
Q

Platelet adhesion process

A

Platelets adhere to a foreign surface

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3
Q

Initiating factor of platelet adhesion

A

Exposure of subendothelial collagen

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4
Q

Effect of damaged endothelial cells on VWF

A

release VWF from storage

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5
Q

VWF behavior upon release

A

VWF unrolls and becomes fibrillar

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6
Q

Platelet binding site for VWF

A

GPIbα portion of GP Ib/IX/V

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7
Q

Nature of VWF-platelet binding

A

Reversible binding that ‘tethers’ or decelerates the platelet

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8
Q

Role of ADAMTS-13 in VWF binding

A

Digests unused VWF to localize platelet-VWF interactions

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9
Q

Effect of GP VI binding to collagen

A

Activates internal platelet pathways and releases TXA2 and ADP

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10
Q

Process initiated by blood vessel injury

A

Exposes collagen, releases VWF, releases tissue factor

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11
Q

Effect of blood vessel injury on collagen

A

Collagen is exposed

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12
Q

Effect of blood vessel injury on VWF

A

VWF is released

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13
Q

Effect of blood vessel injury on tissue factor

A

Tissue factor is released

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14
Q

Platelet adhesion process

A

Platelets adhere to a foreign surface

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15
Q

Initiating factor of platelet adhesion

A

Exposure of subendothelial collagen

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16
Q

Effect of damaged endothelial cells on VWF

A

release VWF from storage

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17
Q

VWF behavior upon release

A

VWF unrolls and becomes fibrillar

18
Q

Platelet binding site for VWF

A

GPIbα portion of GP Ib/IX/V

19
Q

Nature of VWF-platelet binding

A

Reversible binding that ‘tethers’ or decelerates the platelet

20
Q

Role of ADAMTS-13 in VWF binding

A

Digests unused VWF to localize platelet-VWF interactions

21
Q

Effect of GP VI binding to collagen

A

Activates internal platelet pathways and releases TXA2 and ADP

22
Q

Function of TXA2

A

Binds to TPα and TPβ

23
Q

Function of ADP

A

Binds to P2Y1 and P2Y12

24
Q

TXA2 and ADP effect on α2β1 (GP Ia/IIa)

A

Triggers increased affinity for collagen

25
Q

Combined effect of GP Ib/IX/V, GP VI, and α2β1 (GP Ia/IIa)

A

Firm attachment of platelet to damaged surface and spreading

26
Q

TXA2 and ADP effect on platelets

A

Activate adjacent platelets via their receptors

27
Q

TXA2 and ADP effect on αIIbβ3 (GP IIb/IIIa)

A

Provide inside-out activation for platelet aggregation

28
Q

Platelet aggregation process

A

Platelets adhere to other platelets

29
Q

Role of tissue factor (TF) in aggregation

A

Triggers thrombin generation, activating PAR1 and PAR4

30
Q

Coat platelet formation

A

Collagen and thrombin activated platelet integral to cell-based coagulation

31
Q

Function of αIIbβ3 (GP IIb/IIIa)

A

Binds fibrinogen and VWF, supporting platelet-to-platelet aggregation

32
Q

Changes during aggregation

A

Platelets lose shape, extend pseudopods, phosphatidylserine flips

33
Q

Effect of aggregation on membrane integrity

A

Loss of membrane integrity, syncytium of platelet cytoplasm forms

34
Q

Platelet activation triggers

A

Actin microfilament contraction

35
Q

Intermediate filaments function

A

Compress granules by moving microtubules inward

36
Q

Phosphatidylserine role

A

Supports tenase and prothrombinase with ionic calcium

37
Q

α-granule contents

A

Fibrinogen, Factor V, Factor VIII, VWF

38
Q

VWF function

A

Stabilizes Factor VIII

39
Q

Granules’ content flow

A

Through SCCS to plasma membrane

40
Q

Dense granules function

A

Vasoconstrictors and platelet agonists

41
Q

Lysosome function

A

Digest vessel wall matrix and debris

HEMATOLOGY 2 (15 decks)

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