Primary hemostasis

Question 1

Endothelium – simple squamous epithelium lining the blood vessels, First coat of blood vessel wall

Answer 1

Tunica intima (tunica interna)

Question 2

Composed of smooth muscle and elastic fibers, thickest coat, Second coat of blood vessel wall

Answer 2

Tunica media

Question 3

Composed of fibrous connective tissue, contains autonomic nerve endings and vasa vasorum

Third coat of blood vessel wall

Answer 3

Tunica externa (tunica adventitia)

Question 4

Distributing blood vessels that leave the heart, have the thickest walls of the vascular system, size is 4mm

Answer 4

Arteries

Question 5

Microscopic continuation of arteries, give off branches called metarterioles that join capillaries, size is 30 μm

Answer 5

Arterioles

Question 6

blood vessels that return to the heart, larger, more irregular lumen than arteries, size is 5 mm

Answer 6

Veins

Question 7

Microscopically sized veins, connect capillaries to veins, size is 20 μm

Answer 7

Venules

Question 8

Blood passes from the arterial to the venous system via the this blood vessel, size is 8 μm

Answer 8

Capillaries

Question 9

Thinnest walled and most numerous of the blood vessels, composed of one cell layer of simple squamous epithelium

Answer 9

Capillaries

Question 10

Specialized types of capillaries found in the bone marrow, spleen, and liver

Answer 10

Sinusoids

Question 11

hormone that inhibits platelet activation

other name: Prostaglandin I2 (PGI2)

Answer 11

Prostacyclin

Question 12

Prostacyclin is produced by

what pathway?

Answer 12

Eicosanoid pathway in endothelial cells

Question 13

Prostacyclin penetrates the platelet and binds at its

Answer 13

IP receptor

Question 14

Eicosanoid synthesis pathway in endothelial cells produces:

Answer 14

Prostacyclin

inhibits platelet activation

Question 15

Eicosanoid synthesis pathway in platelets

Answer 15

Thromboxane A2 (TXa2)

activates platelet

Question 16

Metabolic product of ATP and ADP, stimulates vasodilation

Answer 16

Adenosine

Question 17

Thrombin cofactor

Binds thrombin and reduces its ability to participate in the clotting process

Answer 17

Thrombomodulin (TM)

Question 18

Thrombomodulin + thrombin activates?

Plasma protein

Answer 18

Protein C

inactivates factors Va and VIIIa

Question 19

Activated Protein C (APC)

Answer 19

Inactivates factors Va and VIIIa

Question 20

Thrombin activatable fibrinolysis inhibitor (TAFI)

Answer 20

Antifibrinolytic enzyme

Question 21

Weakly enhances Antithrombin (formerly Antithrombin III)

Answer 21

Heparan sulfate

Question 22

Metabolic product of ATP and ADP, stimulates vasodilation

Answer 22

Adenosine

Question 23

Thrombin cofactor, binds thrombin and reduces its ability to participate in the clotting process

Answer 23

Thrombomodulin (TM)

Question 24

Thrombomodulin + thrombin activate

Answer 24

Protein C

Question 25

Activated Protein C (APC)

Answer 25

Inactivates factors Va and VIIIa

Question 26

Thrombin activatable fibrinolysis inhibitor (TAFI)

Answer 26

Antifibrinolytic enzyme

Question 27

Weakly enhances Antithrombin (formerly Antithrombin III)

Answer 27

Heparan sulfate

Question 28

Disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13

Answer 28

ADAMTS 13

Question 29

Aka: VWF cleaving protease

Answer 29

ADAMTS 13

Question 30

Plasma enzyme secreted by the liver

Answer 30

ADAMTS 13

Question 31

Regulates the size of circulating VWF by cleaving ultra-long VWF multimers

Answer 31

ADAMTS 13

Question 32

Ultra-long VWF multimers (ULVWF)

Answer 32

Cleaved into shorter segments with less hemostatic potential by ADAMTS 13

Question 33

Caused by deficiency of ADAMTS 13

Answer 33

TTP (Thrombocytopenic Purpura)