Schizophrenia Flashcards

1
Q

What is the medical umbrella schizophrenia falls under?

A

Major psychoses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why is schizophrenia the most important major psychosis?

A

Early onset, prevalence and how disabling and chronic it is

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is schizophrenia (generally)?

A

A mental state out of touch with reality
Abnormalities of perception, thoughts and ideas
Profound alterations in behaviour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the prevalence of schizophrenia?

A

1% of the population

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the difference between men and women’s schizophrenia symptoms?

A

Men onset at a younger age,
Have a higher propensity for negative symptoms,
Lower social functioning
Co-morbid substance abuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What phase may a schizophrenic go through in their late teenage years before the onset of symptoms?

A

Social isolation, withdrawal and an interest in fringe cults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the positive schizophrenia symptoms?

A

Hallucinations
Delusions
Disorganised thought/speech
Movement disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the negative schizophrenia symptoms?

A
Social withdrawal
Anhedonia
Lack of motivation
Poverty of speech
Emotional flatness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some cognitive schizophrenia symptoms?

A

Impaired working memory, attention and comprehension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What has to be present to be classed as schizophrenia?

A

Two or more symptoms for at least six months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is anhedonia?

A

Lack of pleasure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are hallucinations?

A

Perception experienced without stimulus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What type of hallucinations happen most commonly in schizophrenics?

A

Auditory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What happens in auditory hallucinations?

A

Patient hears voices talking about them/ to them, giving a running commentary or echoing their thoughts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is a delusion?

A

Fixed/ unshakeable belief that is not consistent with cultural/ social norms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is a state of catatonia?

A

Motionless, mute, expressionless, uncomfortable or contorted postures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is a state of cataplexy?

A

Sudden loss of muscle control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are some motor, volitional and behavioural disorders associated with schizophrenia?

A
Purposeless, repetitive acts, 
altered facial expression, 
cataplexy, 
catatonia, 
Extreme hyperactivity and impulsive behaviours
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is a formal thought disorder?

A

Disorder in conceptual thinking

20
Q

What is formal thought disorder reflected in?

A

Speech that is difficult to understand and rapid shifts from one subject to another

21
Q

What are some cognitive deficits shown by schizophrenics?

A

Selective attention, problem solving and memory

22
Q

What affect do cognitive deficits have?

A

Decreased responsiveness to emotional issues and expression of emotion being inappropriate to the situation

23
Q

What does it mean that schizophrenics have a lack of insight?

A

Patients don’t normally accept that anything is wrong or that treatment is necessary

24
Q

What is the chance an identical twin will be diagnosed with schizophrenia if the other is?

25
What is the chance one non-identical twin will develop schizophrenia if the other twin does?
14%
26
What are some of the candidate genes suggested to have a role in schizophrenia?
COMT, DISC1, GRM3
27
What are some risk factors for developing schizophrenia?
Mother gets influenza in pregnancy, pregnancy/ birth complications, stress and drug use
28
What are the types of pregnancy/ birth complications that are risk factors for schizophrenics?
Low birthweight, premature birth, asphyxia during birth
29
What drugs can be a risk factor for developing schizophrenia?
Cannabis, amphetamine, cocaine, LSD
30
What are the general pathophysiologies of schizophrenia?
Dopamine hypothesis, brain structure differences, hypofrontility and NMDA receptor evidence
31
What are the two sections in the dopamine hypothesis?
Hyperactivity of the dopaminergic mesolimbic pathway or hypoactivity of the dopaminergic mesocortical pathways
32
What does hyperactivity of the dopaminergic mesolimbic pathway cause?
Positive schizophrenia symptoms
33
What does hypoactivity of the dopaminergic mesocortical pathways cause?
Decreased cognition
34
What is the pharmacological evidence for the dopamine hypothesis?
Amphetamine enhances dopamine release in schizophrenics more than in controls Reserpine depletes DA and controls positive symptoms Strong correlation between D2 blocking acitivity and antipsychotic action
35
What is the evidence against the dopamine hypothesis?
No clear change in the CSF HVA concentration | No change in dopamine receptors in drug-free patients (changes attributed to drug treatments)
36
What is hypofrontility?
Reduced blood flow (and possibly reduced activity) to the frontal cortex
37
What are some brain structure differences in schizophrenics?
Slightly smaller overall brain size Reduced grey matter Enlarged lateral ventricles
38
What are the types of treatment for schizophrenia?
Cognitive behavioural therapy Electroconvulcive therapy (rarely used now) Pharmacological treatments
39
What do antipsychotics do?
Block dopamine D2 receptors which stops hyperactivity of the dopaminergic pathways
40
What are the two classes of antipsychotics?
Typical and atypical
41
What do the typical antipsychotics do?
Mainly antagonise D2 receptors
42
What do atypical antipsychotics do?
Mainly antagonise D2 and serotonin 2A receptors
43
What are the side effects of the D2 receptor blockade acting on the nigrostriatal pathway?
Movement disorders like dystonia, dyskinesia and Parkinsonism
44
What are the side effects of the D2 receptor blockade acting on the pituitary gland?
Prolactin release causing breast swelling, lactation and impotence
45
What are the side effects of the alpha adrenoreceptor receptor blockade?
Postural hypotension, nasal congestion and hypothermia
46
What are some other side effects of antipsychotics?
Sedation, weight gain and photosensitisation