Schizo

Question 1

Vier A’s van Beuler

Answer 1

Ambivalentie (geen keuzes kunnen maken)
Affect (vervlakt effect)
Autisme (verminderd sociale interacties)
Associatiezwakte (Geen verbanden kunnen leggen)

Question 2

Positieve en negatieve

Answer 2

+: Hallucinaties en dellusions

- : Affect, ambivalentie en autisme

Question 3

Incidentie

Answer 3

15 per 100.000
Meer bij migranten dan autochtonen
Hoger in steden dan op platteland.
Life prev is 0,04

Question 4

Ultra High risk paradigm UHR

Answer 4

Collection of symptoms that are highly predictive of psychiatric disorders in the next three years.

Question 5

Biomarkers

Answer 5

must help with diagnosis, prognosis and treatment response. Dopamine is one

Question 6

Block and activate

Answer 6

Agonist = activator
Antagonist = blocker

Question 7

Dopa hypothesis

Answer 7

Dopamine might enlarge salience, and use of antipsychotic drugs has to do with dopamine. Has severe side effects ( parkinsonism). Limitations:

Only on positive symptoms, not in all patients, does not explaiin efficacy of other meds, simplistic view, dopamine is all around cortex

Question 8

Glutamate hypothesis

Answer 8

NMDA receptor antagonism for negative and postive symptoms eg ketamine
NMDA is off in schizo, keta targets -, + and cognitive symtpoms

Question 9

Cog impairments and style

Answer 9

impairment: Speed of process, attention, working memory, learning and social cognition

Styles: Jumping to conclusions, source monitoring bias, bias against disconfirmatory evidence and self-serving bias