SBL Learning Issues Flashcards
1
Q
What is the big difference between LDL and HDL cholesterol?
A
The more lipids a cholesterol particle has, the lower its density. Therefore, HDL has less lipids than LDL
2
Q
How can the corticotroph pathway of hormones lead to hyperpigmentation and striae?
A
Excess ACTH simulates melanocytes to produce melanin, thus causing skin hyperpigmentation
3
Q
Why could diabetes cause wounds to take longer to heal?
A
Peripheral nerve damage could decrease rate at which wounds heal.
4
Q
Describe the beta cell insulin release mechanism
A
- Glucose increase
- Respiration increase
- ATP increase
- ATP dependent K+ channels open
- Increased K+ retention
- Membrane depolarises
- Voltage gated calcium channels allow Ca2+ influx
- Vesicles containing insulin fuse with cell membrane, releasing insulin into the bloodstream
5
Q
Which types of pancreatic endocrine cells release glucagon/insulin?
A
Glucagon: alpha
Insulin: beta
6
Q
What is the first step in any disease mechanism?
A
Risk factors
