7.5 Flashcards

1
Q

Describe the metabolic actions of growth hormone

A
  • Increased protein synthesis
  • Decreased proteloysis
  • Increased lipolysis
  • Gluconeogenesis
  • Decreased muscle insulin sensitivity
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2
Q

What type of hormone is growth hormone?

A

Peptide (think about what kinds of receptors this could bind to)

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3
Q

What stimuli can lead to release of growth hormone?

A
  • Exercise
  • Stress
  • Hypoglycaemia
  • Fasting (since IGF-1 is low)
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4
Q

What are some stimuli that decrease growth hormone secretion?

A
  • IGF
  • GH (stimulate GHIH)
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5
Q

What is another name for somatomedins?

A

Insulin-like growth factors

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6
Q

What is another name for somatomedins?

A

Insulin-like growth factors

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7
Q

Describe the growth-promoting actions of growth hormone. Which hormone does this largely occur through?

A
  • Increased protein synthesis
  • Decreased proteolysis
  • Hyperplasia
  • Hypertrophy

Occurs largely via IGF-1

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8
Q

Describe action of GH on bone growth

A
  • Stimulates proliferation of epiphyseal cartilage
  • Increased bone remodelling
  • Proliferation of osteoblasts
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9
Q

What is a potential cause of GH hypersecretion?

A

Pituitary tumour (during childhood: gigantism, in adulthood: acromegaly)

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10
Q

What are some potential causes of GH hyposecretion?

A
  • Lack of GHRH
  • Hypothalamic tumour/injury
  • Social/psychological factors
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11
Q

Key role of FSH in males

A

Sperm production

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12
Q

Key role of LH in males

A

Testosterone secretion

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13
Q

Key role of FSH In females

A
  • Follicle development
  • LH receptors on dominant follicle
  • Oestrogen secretion
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14
Q

Key role of LH in females

A
  • Acute surge in ovulation
  • Maintains corpus luteum
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15
Q

How is gonadotropin release mediated?

A

Pulsatile secretion pattern of GnRH, which is in turn regulated by negative feedback from steroid and peptide hormones (oestrogen and testosterone)

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