SARS-CoV-2 Flashcards

1
Q

SARS-CoV

A

Severe Acute Respiratory Virus

Appeared in humans 02-03

Caused just over 8000 cases, easily controllable with standard disease control (Contact tracing)

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2
Q

MERS-CoV

A

Middle East Respiratory Syndrome

(2012-)

Still circulating in middle east (thought to originate from camels, which received it from another species)

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3
Q

Does hydroxychloroquine work for covid

A

ffs no it does not

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4
Q

Remdesivir

A

Anti-viral drug shown to improve recovery period in Covid-19 patients - does not seem to have impact on mortality

Causes termination of RNA synthesis

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5
Q

Dexamethasone

A

Covid-19 treatment shown to have a positive effect on mortality

Anti-inflammatory

Cheap (old drug)

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6
Q

Passive immunisation against covid-19

A
Convalescent plasma (plasma from previously infected patients)
 - not very effective

Monoclonal antibodies
- effective but is at risk of redundancy through antigenic drift

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7
Q

Monoclonal antibodies used against Covid-19

A

Ronapreve, Sotrovimab

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8
Q

Molnupiravir

A

Antiviral drug against Covid-19

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9
Q

Tociluzamab

A

Anti-IL6 monoclonals; used to treat covid-19

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10
Q

Are anti-coagulants used to treat covid-19

A

Yes (probably)

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11
Q

Describe the nucleic acids of SARS-CoV-2

A

Positive-sense ssRNA

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12
Q

RBD

A

Receptor binding domain; responsible for the virus binding to host cells

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13
Q

Coronavirus replication cycle

A

Virus binds to cell receptor

Entry by endocytosis

Fusion of viral envelope with endocytotic membrane to uncoat the genome

Genome is copied; translated

Assembly of replicated RNA and proteins

Virus released

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14
Q

ACE2

A

Angiotensin Converting Enzyme 2

Receptor that SARS-CoV-2 binds to (on human cells)

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15
Q

ChadOx1

A

Oxford Vaccine for Covid-19

Uses chimpanzee adenovirus modified to avoid replication

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