SARS-CoV-2 Flashcards
SARS-CoV
Severe Acute Respiratory Virus
Appeared in humans 02-03
Caused just over 8000 cases, easily controllable with standard disease control (Contact tracing)
MERS-CoV
Middle East Respiratory Syndrome
(2012-)
Still circulating in middle east (thought to originate from camels, which received it from another species)
Does hydroxychloroquine work for covid
ffs no it does not
Remdesivir
Anti-viral drug shown to improve recovery period in Covid-19 patients - does not seem to have impact on mortality
Causes termination of RNA synthesis
Dexamethasone
Covid-19 treatment shown to have a positive effect on mortality
Anti-inflammatory
Cheap (old drug)
Passive immunisation against covid-19
Convalescent plasma (plasma from previously infected patients) - not very effective
Monoclonal antibodies
- effective but is at risk of redundancy through antigenic drift
Monoclonal antibodies used against Covid-19
Ronapreve, Sotrovimab
Molnupiravir
Antiviral drug against Covid-19
Tociluzamab
Anti-IL6 monoclonals; used to treat covid-19
Are anti-coagulants used to treat covid-19
Yes (probably)
Describe the nucleic acids of SARS-CoV-2
Positive-sense ssRNA
RBD
Receptor binding domain; responsible for the virus binding to host cells
Coronavirus replication cycle
Virus binds to cell receptor
Entry by endocytosis
Fusion of viral envelope with endocytotic membrane to uncoat the genome
Genome is copied; translated
Assembly of replicated RNA and proteins
Virus released
ACE2
Angiotensin Converting Enzyme 2
Receptor that SARS-CoV-2 binds to (on human cells)
ChadOx1
Oxford Vaccine for Covid-19
Uses chimpanzee adenovirus modified to avoid replication