Hypersensitivity and Allergy Flashcards
What does an exaggerated response cause
Tissue damage (hypersensitibity)
Allergy Hypersensitivity vs Autoimmunity Hypersensitivity
Allergy - foreign material recognised but self material damaged
Autoimmunity - Self material recognised and self material damaged
Type 1 hypersensitivity
Immediate hypersensitivity or atopic allergy
Caused by IgE being cross linked on the surface of mast cells
What are type 2,3 and 4 hypersensitivities referred to as
Type 2 Hypersensivity - Antibody dependent hypersensitivity
Type 3 Hypersensitivity - Immune complex hypersensitvity
Type 4 Hypersensitivity - Delayed time hypersensitvity
*note that type 4 is mediated by cells not antibodies
What 3 factors mediate type I hypersensitivity
Mast Cells
IgE
Allergens
Examples of Type I Allergies
Allergic rhinitis (hayfever) Allergic Asthma Eczema Food Allergies Anaphylaxis
(don’t memorise just be vaguely aware)
What does the mast cell cause during type I allergy
Release of mediators causing oedema and smooth muscle contraction
Sensitisation
Allergen crosses the mucosal surfaces and enters body
Phagocytosed into APC
Does the same for allergen as it would for antigen; presents on MHC complex II
Peptide of that protein is presented to a TH2 cell
TH2 cell causes class switching in B cells to produce IgE antibodies against that allergen that sit on the surface of the mast cell via their Fc receptors
Which interleukins are released by Th2 cells during type I hypersensitivity and what do they each do
IL10: inhibits Th1 activity and activates mast cells
IL4: Activates B cells and causes class switching
IL5: Activates Eosinophils
What happens on subsequent exposure to the same allergen (Elicitation)
Mast cell degranulates as the IgE antibodies are bound - releases inflammatory mediators which lead to the allergic reaction
Atopic subject
Person predisoposed to having high levels of IgE
thus predisposed to allergies
such as hay fever, perennial rhinitis, asthma and atopic eczema
What are some mediators released during reactions of type I hypersensitivity
Histamine Heparin Tryptase Arachidonic Acid Leukotrienes-D4 Prostaglandin-D2 TNFa IL-4
Would there be an anaphalactic response to a bee sting on the first time? Why/Why not?
No IgE antibodies against phospholipase A (protein causing reaction) have been made that are bound to mast cells
Why do dust-mites cause allergy
We do not have an allergic response to the mites themselves; instead we have a response to their faecal matter
Route of Entry and Bodily Response for Systemic Anaphylaxis
Route of Entry:
Intravenous either directly or through absorption of food into blood
Reponse: Full body mast cell degranulation Oedema Increased Vascular Permeability Tracheal Occlusion Circulatory Collapse Death