Rotenone

Question 1

T/F: rotenone is a synthetic compound

Answer 1

false, it occurs naturally in seeds and stems of several plants

Question 2

Rotenone is approved by EPA  to remove:
A) fungus
B) pests
C) fish
D) weeds

Answer 2

C - it is a peiscicide

Question 3

Most toxic route of absorption of rotenone?

Answer 3

inhalation - direct pathway to circulatory system

Question 4

Toxicity of rotenone?

Answer 4

neurotoxic

Question 5

How are fish exposed to rotenone?

Answer 5

passes directly into bloodstream through gills or trachea

Question 6

MoA of rotenone

Answer 6

blocks oxidative phosphorylation in TCA cycle
interferes with electron transport chain and NADH during ATP production
cellular oxygen reduced resulting in ROS
causes oxidative stress damaging DNA and organelle resulting in neuronal cell death

Question 7

General clinical Signs of rotenone toxicity

Answer 7

dermal exposure - local irritation (conjunctivitis, congestion, dermatitis
Oral exposure - GI irritant, convulsions, muscle tremors, lethargy, incontinence and resp stimulation followed by depression
resp exposure - severe pulmonary irritation and asphyxia

Question 8

Predominante clinical signs of rotenone toxicity

Answer 8

is a neurotoxin so depression and convulsions

Question 9

Diagnosis of rotenone

Answer 9

Lab
- antemortem see hypoglycaemia, liver enzyme changes, hypoxemia/hypercapnea
Dx - Hx, check with fish authorities

Question 10

Treatment of rotenone toxicity

Answer 10

no specific Tx, rapidly metabolized
supportive treatment (tx seizures and hypoglycaemia)