DEET

Question 1

MoA of DEET

Answer 1

undetermined

known to affect olfactory and nervous system

Question 2

T/F: DEET potentiates effects of carbamates and Acetylcholinesterase inhibitors

Answer 2

true

Question 3

Toxicity of DEET

Answer 3

slightly toxic to freshwater fish and zoo plankton

dogs and cats susceptible, cats more sensitive

Question 4

You are going camping and pack a bunch of high % deet mosquito repellent for yourself. You want to bring your dog along but dont want him to get a bunch of mosquito bites. Can you share your deet with him?

Answer 4

No! DEET for human use not recommended for use on pets

Question 5

Toxicokinetics of DEET

Answer 5

dermal absorption or GI tract
metabolized in liver, excreted in urine
can increase dermal absorption of other products

Question 6

Clinical signs of DEET toxicity

Answer 6

rabbits/rats - depression, excitation, ataxia, tremors, seizures, coma
Dogs/cats - hyper salivation, vomiting, hyperexcitability, tremors, ataxia, seizures, skin + MM irritations

Question 7

Diagnosis of DEET toxicity

Answer 7

History,presentation

20ppm is diagnostic in chemical analysis

Question 8

Treatment of DEET toxicity

Answer 8

no specific antidote
decontamination
avoid magnesium cathartic because may cause CNS depression