Cocaine

Question 1

Use of cocaine

Answer 1

topical local anesthetic for oral, laryngeal and nasal cavities
can confirm cause of miotic pupil in conditions such as Horner’s

Question 2

Plant of cocaine origin

Answer 2

Erythroxylon coca or E. monogynum

Question 3

Toxicity of cocaine

Answer 3

dogs most susceptible, especially police dogs

Question 4

Toxicokinetics of cocaine

Answer 4

highly lipid soluble ester
absorbed from all MM
crosses BBB and alveolar capillary

Question 5

MoA of cocaine toxicosis

Answer 5

CNS stimulant and sympathomimetic
blocks reuptake of norepinephrine, dopamine and serotonin
increases catecholamine release
has direct effect on myocardium

Question 6

Clinical signs of cocaine toxicosis

Answer 6

vomiting
hypersalivation
mydriasis
hyperactivity
tremors
convulsive seizures
hyperthermia
tachycardia
tachypnea

Question 7

Lesions associated with cocaine toxicosis

Answer 7

myocardial degeneration
subendocardial and epicardial hemorrhage
pericardial effusion
pulmonary hemorrhage

Question 8

Treatment of cocaine toxicosis

Answer 8

including vomiting
gastric lavage with activate charcoal
diazepam IV to control seizures
B-blockers for tacharrhythmias