Rosai Chapter 8 - Thyroid Gland

Question 1

Development of Thyroid gland

-cords and plates of follicular cells are formed microscopically

Answer 1

9th week

Question 2

Development of Thyroid gland

-small follicular lumina appear

Answer 2

10th week

Question 3

Development of Thyroid gland

-Colloid secretion become evident

Answer 3

12th week

Question 4

Development of Thyroid gland

-gland consists of well-developed follicles lined by follicular cells and containing thyroglobulin-positive colloid in the lumen

Answer 4

14th week

Question 5

Specific transcription factors that control the development of the thyroid gland (5)

Answer 5

• TTF-1 (NKX 2-1)
• TTF-2 (FoxE1)
• PAX8
• HHEX
• NKX 2-5

Question 6

Functional maturation requires the activity of… (3)

Answer 6

• TSH
• TSHr
• Gs alpha

Question 7

Pretracheal node located near the isthmus

Answer 7

Delphian node

Question 8

Follicular cells with abundant granular acidophilic cytoplasm (4):

Answer 8

• Hurthle cells
• Askanazy cells
• Oxyphilic cells
• Oncocytes

Question 9

Main ultrastructural features of follicular cells (4)

Answer 9

• Abundant granular endoplasmic reticulum
• well-developed Golgi apparatus
• Lysosomes
• numerous Microvilli in the luminal border

Question 10

An ultrastructural feature of follicular cells that is numerous in actively secreting cells and mainly located toward the apical side

Answer 10

-Lysosomes

Question 11

Most widely used marker in thyroid gland

Answer 11

Thyroglobulin

Question 12

NIS or Pendrin & Anoctamin-1 (ANO1)

Sodium iodide symporter

Answer 12

NIS

Question 13

NIS or Pendrin & Anoctamin-1 (ANO1)

mediates active iodide uptake

Answer 13

NIS

Question 14

NIS or Pendrin & Anoctamin-1 (ANO1)

-Basolateral

Answer 14

NIS

Question 15

NIS or Pendrin & Anoctamin-1 (ANO1)

-expressed at higher level in normal thyroid gland

Answer 15

NIS

Question 16

NIS or Pendrin & Anoctamin-1 (ANO1)

-Transmembrane member of Discovered on GIST1 (DOG1)

Answer 16

Pendrin & Anoctamin-1 (ANO1)

Question 17

NIS or Pendrin & Anoctamin-1 (ANO1)

-for passive iodide efflux towards follicular lumen

Answer 17

Pendrin & Anoctamin-1 (ANO1)

Question 18

NIS or Pendrin & Anoctamin-1 (ANO1)

-Apical

Answer 18

Pendrin & Anoctamin-1 (ANO1)

Question 19

Extemely useful marker for all types of primary and metastatic (including medullary carcinoma) thyroid carcinoma

Answer 19

• TTF-1

* Except for Anaplastic carcinoma

Question 20

May be the best to demonstrate the thyroid origin of anaplastic carcinoma

Answer 20

PAX8

Question 21

Locatio of C cells or Parafollicular cells

Answer 21

-Middle and upper thirds of the lateral lobes along their central axes

Question 22

Characteristics of C cells (3)

Answer 22

• Argyrophilic with Grimelius reaction
• Metachromatic with toluidine blue
• Positive for lead hematoxylin

Question 23

IHC of solid cell nests (2)

Answer 23

• HMW Keratin

- CEA

Question 24

Most frequent location of Heterotopic thyroid tissue

Answer 24

-Base of the tongue

Question 25

Isosceles triangle where large majority of heterotopic thyroid tissue are formed

Answer 25

Wöfler area

Question 26

Base or Apex of Wöfler area:

-Edge of the Mandible

Answer 26

Base

Question 27

Base or Apex of Wöfler area:

-Concavity of the Aortic arch

Answer 27

Apex