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PATHOLOGY > Rosai Chapter 2 - Dermatoses > Flashcards

Rosai Chapter 2 - Dermatoses Flashcards

1
Q

HYPERKERATOSIS vs. PARAKERATOSIS

Stratum corneum is Thickened

A

HYPERKERATOSIS

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2
Q

HYPERKERATOSIS vs. PARAKERATOSIS

More prominent granular layer

A

HYPERKERATOSIS

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3
Q

HYPERKERATOSIS vs. PARAKERATOSIS

Cells of stratum corneum retain their nucleus

A

PARAKERATOSIS

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4
Q

HYPERKERATOSIS vs. PARAKERATOSIS

Diminished or absent granular layer

A

PARAKERATOSIS

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5
Q

Pilar Unit (4)

A

“SHEA”

  1. Sebaceous gland
  2. Hair follicle
  3. Erector pili muscle
  4. Apocrine gland (in certain regions)
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6
Q

Four IHCs positive in both Eccrine and Apocrine glands

A
  • CEA
  • EMA
  • Keratin
  • S100
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7
Q

Four enzymatic IHCs positive in both Eccrine and Apocrine glands

A
  • Carbonic anhydrase
  • Ferritin
  • Secretory Ig
  • SPI
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8
Q

IHC positive only in Apocrine gland

A

-GCDFP-15

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9
Q

Key feature of Stasis Dermatitis

A

-presence of lobular proliferation of relatively thick-walled blood vessels in the papillary dermis

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10
Q

Most common form of Psoriasis

A

Psoriasis vulgaris

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11
Q

Most important prognostic determinator of Graft-vs-Host Disease

A

-Amount of inflammation

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12
Q

Lerner Grading System of Acute GVHD

-Basal vacuolization with a superficial perivascular lymphocytic infiltrate without dyskeratotic keratinocytes

A

Grade I

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13
Q

Lerner Grading System of Acute GVHD

-Features of Grade I with dyskeratotic keratinocytes and satellite necrosis

A

Grade II

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14
Q

Lerner Grading System of Acute GVHD

-Most cases

A

Grade II

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15
Q

Lerner Grading System of Acute GVHD

-Cleft formation between the epidermis and dermis

A

Grade III

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16
Q

Lerner Grading System of Acute GVHD

-Complete loss of the epidermis

A

Grade IV

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17
Q

Most common cutaneous lesion of acute/systemic lupus erythematosus

A

Erythematous bimalar “butterfly” blush

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18
Q

Most common type of adverse medication reaction

A

Morbilliform drug eruptions

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19
Q

Most common clinical form of pigmented purpuric dermatosis

A

Schamberg disease

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20
Q

Other name of Malignant Atrophic Papulosis

A

Degos disease

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21
Q

Main chain microscopically of Malignant Atrophic Papulosis

A

ischemic wedge-shaped infarct of the skin

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22
Q

Three histochemical stains used to stain Mast cells

A
  • Toluidine blue
  • Giemsa
  • Leder cytochemical stains
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23
Q

Three IHC stains for Mast cells

A
  • Tryptase
  • Calretinin
  • CD117 (c-Kit)
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24
Q

Most common individuals with Acute Febrile Neutrophilic Dermatosis

A

Middle-aged Women

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25
Q

other name of Acute Febrile Neutrophilic Dermatosis

A

Sweet syndrome

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26
Q

Most common presentation of B-cutaneous lymphoid hyperplasia

A

in head and neck as solitary erythematous to violaceous plaques or nodules in adults

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27
Q

Main differential diagnosis of B-cutaneous lymphoid hyperplasia (2)

A
  • cutaneous marginal zone lymphoma

- cutaneous follicle center lymphoma

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28
Q

Key component histologically of Granuloma Annulare

A

necrobiotic or palisading granuloma

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29
Q

POSITIVE or NEGATIVE

IHC of “Histiocytes” in Granuloma Annulare:

-Vimentin

A

Positive

30
Q

POSITIVE or NEGATIVE

IHC of “Histiocytes” in Granuloma Annulare:

-Lysozyme

A

Positive

31
Q

POSITIVE or NEGATIVE

IHC of “Histiocytes” in Granuloma Annulare:

-HAM-56

A

Negative

32
Q

POSITIVE or NEGATIVE

IHC of “Histiocytes” in Granuloma Annulare:

-KP-1 (CD68)

A

Negative

33
Q

Most common form of Scleroderma in childhood

A

-Morphea

34
Q

Dominant microscopic change in scleroderma

A

increase in the amount of collagen

35
Q

EOSINOPHILIC FASCIITIS vs. SCLERODERMA

-Marked inflammation

A

Eosinophilic fasciitis

36
Q

EOSINOPHILIC FASCIITIS vs. SCLERODERMA

-thickening of the deep fascia

A

Eosinophilic fasciitis

37
Q

EOSINOPHILIC FASCIITIS vs. SCLERODERMA

-with or without eosinophils

A

Eosinophilic fasciitis

38
Q

EOSINOPHILIC FASCIITIS vs. SCLERODERMA

-minimal or no abnormalities

A

Scleroderma

39
Q

Two prototypical panniculitis

A
  • Erythema Nodosum

- Nodular vasculitis

40
Q

Prototypical Septal Panniculitis

A

Erythema Nodosum

41
Q

Prototypical Lobular Panniculitis

A

Nodular Vasculitis

42
Q

Most common form of primary panniculitis (70-80%)

A

-Erythema nodosum

43
Q

Characteristic lesion seen in early stages of Erythema nodosum

A

Miescher radial granuloma

44
Q

Defined as cluster of small histiocytes radially arranged around a central cleft

A

Miescher radial granuloma

45
Q

Key morphologic features in the microscopic evaluation of vesiculobullous lesions (2)

A
  • level of the plane of separation

- type of cellular change seen, particularly presence or absence of acantholysis

46
Q

Most common form of Bullous pemphigoid

A

generalized cutaneous pemphigoid

47
Q

Most consistent histologic feature of bullous pemphigoid

A

-subepidermal blister above the basement membrane that contains numerous inflammatory cells including frequent eosinophils in the blister cavity

48
Q

EPIDERMOLYSIS BULLOSA ACQUISITA vs. PEMPHIGOID

Immune deposits of salt-split skin preparations examined with direct immunofluorescence

-in the floor of the blister

A

EPIDERMOLYSIS BULLOSA ACQUISITA

49
Q

EPIDERMOLYSIS BULLOSA ACQUISITA vs. PEMPHIGOID

Immune deposits of salt-split skin preparations examined with direct immunofluorescence

-roof of the blister

A

PEMPHIGOID

50
Q

Most useful criterion histologically for the diagnosis of dermatitis herpetiformis

A

presence of papillary microabscesses forming a multilocular subepidermal bulla

51
Q

Most important clue to the diagnosis of transient acantholytic dermatosis

A

association of Acantholysis and Spongiosis

52
Q

other name of Transient Acantholytic Dermatosis

A

Grover disease

53
Q

Viral lesions of skin most commonly seen histologically as (2)

A
  • Warts

- Condylomas

54
Q

Characteristics of viral nuclear inclusions (3):

A
  • Basophilic
  • Feulgen positive
  • DNAse resistant
55
Q

Patients with these diseases are particularly prone to develop herpes zoster infection (2)

A
  • Leukemia

- Malignant lymphoma

56
Q

Most important pathogens of hidradenitis suppurativa

A

Anaerobic organisms

57
Q

Organisms most commonly implicated in atypical mycobacteriosis (3):

A
  • Mycobacterium kansasii
  • M. marinum
  • M. ulcerans
58
Q

Type of Leprosy:

-Lepra or Virchow cells, filled with acid fast bacilli, are plentiful

A

-Lepromatous and Dimorphic leprosy

59
Q

Type of Leprosy:

-bacilli are very scanty

A

-Tuberculoid and Indeterminate leprosy

60
Q

PRIMARY vs. SECONDARY Syphilis

-Spirochetes are mixed epitheliotropic and vasculotropic pattern

A

Primary Syphilis

61
Q

PRIMARY vs. SECONDARY Syphilis

-Spirochetes almost confined to lower levels of the epidermis in an intercellular distribution

A

Secondary Syphilis

62
Q

Pathognomonic of Lyme disease

A

Erythema chronicum migrans

63
Q

Predominant microscopic finding in early stages of Lyme disease

A

-superficial and deep perivascular infiltrate largely composed of lymphocytes but also containing plasma cells and/or eosinophils

64
Q

Also called when bacterial folliculitis and perifolliculitis are superimposed on tinea in the Scalp

A

Kerion celsi

65
Q

Also called when bacterial folliculitis and perifolliculitis are superimposed on tinea in Beard

A

Sycosis barbae

66
Q

Most common organism involved in Majocchi granuloma

A

Trichophyton rubrum

67
Q

other name of Majocchi granuloma

A

Nodular Granulomatous Perifolliculitis

68
Q

Clue to the diagnosis of foreign-body reaction due to aluminum

A

finding of histiocytes with a violaceous granular cytoplasm

69
Q

Carney complex (4):

A

“CASE”

  • Cardiac myxomas
  • superficial Angiomyxomas (cutaneous myxomas)
  • Spotty hyperpigmentation
  • Endocrine hyperactivity
70
Q

Two major forms of Acanthosis nigricans

A
  1. Associated with internal malignant neoplasms (particularly GIT)
  2. Heterogeneous group of disorders having a common denominator, the presence of tissue resistance to insulin

PATHOLOGY (26 decks)

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