Rosai Chapter 2 - Dermatoses Flashcards by Jonathan Emmanuel Cancio

Q

HYPERKERATOSIS vs. PARAKERATOSIS

Stratum corneum is Thickened

A

HYPERKERATOSIS

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

HYPERKERATOSIS vs. PARAKERATOSIS

More prominent granular layer

A

HYPERKERATOSIS

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

HYPERKERATOSIS vs. PARAKERATOSIS

Cells of stratum corneum retain their nucleus

A

PARAKERATOSIS

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

HYPERKERATOSIS vs. PARAKERATOSIS

Diminished or absent granular layer

A

PARAKERATOSIS

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Pilar Unit (4)

A

“SHEA”

Sebaceous gland
Hair follicle
Erector pili muscle
Apocrine gland (in certain regions)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Four IHCs positive in both Eccrine and Apocrine glands

A

CEA
EMA
Keratin
S100

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Four enzymatic IHCs positive in both Eccrine and Apocrine glands

A

Carbonic anhydrase
Ferritin
Secretory Ig
SPI

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

IHC positive only in Apocrine gland

A

-GCDFP-15

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Key feature of Stasis Dermatitis

A

-presence of lobular proliferation of relatively thick-walled blood vessels in the papillary dermis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most common form of Psoriasis

A

Psoriasis vulgaris

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most important prognostic determinator of Graft-vs-Host Disease

A

-Amount of inflammation

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lerner Grading System of Acute GVHD

-Basal vacuolization with a superficial perivascular lymphocytic infiltrate without dyskeratotic keratinocytes

A

Grade I

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lerner Grading System of Acute GVHD

-Features of Grade I with dyskeratotic keratinocytes and satellite necrosis

A

Grade II

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lerner Grading System of Acute GVHD

-Most cases

A

Grade II

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lerner Grading System of Acute GVHD

-Cleft formation between the epidermis and dermis

A

Grade III

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lerner Grading System of Acute GVHD

-Complete loss of the epidermis

A

Grade IV

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most common cutaneous lesion of acute/systemic lupus erythematosus

A

Erythematous bimalar “butterfly” blush

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most common type of adverse medication reaction

A

Morbilliform drug eruptions

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most common clinical form of pigmented purpuric dermatosis

A

Schamberg disease

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Other name of Malignant Atrophic Papulosis

A

Degos disease

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Main chain microscopically of Malignant Atrophic Papulosis

A

ischemic wedge-shaped infarct of the skin

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Three histochemical stains used to stain Mast cells

A

Toluidine blue
Giemsa
Leder cytochemical stains

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Three IHC stains for Mast cells

A

Tryptase
Calretinin
CD117 (c-Kit)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most common individuals with Acute Febrile Neutrophilic Dermatosis

A

Middle-aged Women

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

other name of Acute Febrile Neutrophilic Dermatosis

Sweet syndrome

Most common presentation of B-cutaneous lymphoid hyperplasia

in head and neck as solitary erythematous to violaceous plaques or nodules in adults

Main differential diagnosis of B-cutaneous lymphoid hyperplasia (2)

- cutaneous marginal zone lymphoma | - cutaneous follicle center lymphoma

Key component histologically of Granuloma Annulare

necrobiotic or palisading granuloma

POSITIVE or NEGATIVE IHC of "Histiocytes" in Granuloma Annulare: -Vimentin

Positive

POSITIVE or NEGATIVE IHC of "Histiocytes" in Granuloma Annulare: -Lysozyme

Positive

POSITIVE or NEGATIVE IHC of "Histiocytes" in Granuloma Annulare: -HAM-56

Negative

POSITIVE or NEGATIVE IHC of "Histiocytes" in Granuloma Annulare: -KP-1 (CD68)

Negative

Most common form of Scleroderma in childhood

-Morphea

Dominant microscopic change in scleroderma

increase in the amount of collagen

EOSINOPHILIC FASCIITIS vs. SCLERODERMA -Marked inflammation

Eosinophilic fasciitis

EOSINOPHILIC FASCIITIS vs. SCLERODERMA -thickening of the deep fascia

Eosinophilic fasciitis

EOSINOPHILIC FASCIITIS vs. SCLERODERMA -with or without eosinophils

Eosinophilic fasciitis

EOSINOPHILIC FASCIITIS vs. SCLERODERMA -minimal or no abnormalities

Scleroderma

Two prototypical panniculitis

- Erythema Nodosum | - Nodular vasculitis

Prototypical Septal Panniculitis

Erythema Nodosum

Prototypical Lobular Panniculitis

Nodular Vasculitis

Most common form of primary panniculitis (70-80%)

-Erythema nodosum

Characteristic lesion seen in early stages of Erythema nodosum

Miescher radial granuloma

Defined as cluster of small histiocytes radially arranged around a central cleft

Miescher radial granuloma

Key morphologic features in the microscopic evaluation of vesiculobullous lesions (2)

- level of the plane of separation | - type of cellular change seen, particularly presence or absence of acantholysis

Most common form of Bullous pemphigoid

generalized cutaneous pemphigoid

Most consistent histologic feature of bullous pemphigoid

-subepidermal blister above the basement membrane that contains numerous inflammatory cells including frequent eosinophils in the blister cavity

EPIDERMOLYSIS BULLOSA ACQUISITA vs. PEMPHIGOID Immune deposits of salt-split skin preparations examined with direct immunofluorescence -in the floor of the blister

EPIDERMOLYSIS BULLOSA ACQUISITA

EPIDERMOLYSIS BULLOSA ACQUISITA vs. PEMPHIGOID Immune deposits of salt-split skin preparations examined with direct immunofluorescence -roof of the blister

PEMPHIGOID

Most useful criterion histologically for the diagnosis of dermatitis herpetiformis

presence of papillary microabscesses forming a multilocular subepidermal bulla

Most important clue to the diagnosis of transient acantholytic dermatosis

association of Acantholysis and Spongiosis

other name of Transient Acantholytic Dermatosis

Grover disease

Viral lesions of skin most commonly seen histologically as (2)

- Warts | - Condylomas

Characteristics of viral nuclear inclusions (3):

- Basophilic - Feulgen positive - DNAse resistant

Patients with these diseases are particularly prone to develop herpes zoster infection (2)

- Leukemia | - Malignant lymphoma

Most important pathogens of hidradenitis suppurativa

Anaerobic organisms

Organisms most commonly implicated in atypical mycobacteriosis (3):

- Mycobacterium kansasii - M. marinum - M. ulcerans

Type of Leprosy: -Lepra or Virchow cells, filled with acid fast bacilli, are plentiful

-Lepromatous and Dimorphic leprosy

Type of Leprosy: -bacilli are very scanty

-Tuberculoid and Indeterminate leprosy

PRIMARY vs. SECONDARY Syphilis -Spirochetes are mixed epitheliotropic and vasculotropic pattern

Primary Syphilis

PRIMARY vs. SECONDARY Syphilis -Spirochetes almost confined to lower levels of the epidermis in an intercellular distribution

Secondary Syphilis

Pathognomonic of Lyme disease

Erythema chronicum migrans

Predominant microscopic finding in early stages of Lyme disease

-superficial and deep perivascular infiltrate largely composed of lymphocytes but also containing plasma cells and/or eosinophils

Also called when bacterial folliculitis and perifolliculitis are superimposed on tinea in the Scalp

Kerion celsi

Also called when bacterial folliculitis and perifolliculitis are superimposed on tinea in Beard

Sycosis barbae

Most common organism involved in Majocchi granuloma

Trichophyton rubrum

other name of Majocchi granuloma

Nodular Granulomatous Perifolliculitis

Clue to the diagnosis of foreign-body reaction due to aluminum

finding of histiocytes with a violaceous granular cytoplasm

Carney complex (4):

"CASE" - Cardiac myxomas - superficial Angiomyxomas (cutaneous myxomas) - Spotty hyperpigmentation - Endocrine hyperactivity

Two major forms of Acanthosis nigricans

1. Associated with internal malignant neoplasms (particularly GIT) 2. Heterogeneous group of disorders having a common denominator, the presence of tissue resistance to insulin