Role Of HOrmone In Metabolism Flashcards
Major glucose transport in beta cells, facilitated diffusion of glucose and then metabolism initiated by hexokinase/glucokinase
- pancreatic beta cells, liver, small intestine
GLUT2
How is insulin released from cells?
Glucose > Glycolysis > high ATP : ADP
- vK channels close with high intracell K level
- vCa open with Ca influx, ER release Ca
- high I travel Ca causes signal cascade to release insulin
Hormones and amino acids that stimulate Insulin release
Ach (parasympathetic nervous system) > rest and digest
Arg and Leu
CCK > beta cells
- GLP1 and GIP
What is a strong inhibitor of insulin release?
Nor Epi > fight or flight
GLUT transporter for skeletal, cardiac, and adipose tissue:
- Insulin dependent
GLUT4
GLUT transporter for red blood cells and BBB:
GLUT1
GLUT transporter for neurons, highest affinity:
GLUT3
GLUT4 transporter located in cell:
Found in PM, and fuse when stimulated by insulin
What type of infusion is glucose transport into cell?
Facilitated diffusion
What is the role of insulin on glycogen?
Stimulates glycogen synth
- inhibited glycogen breakdown
- inhibits glucose oogenesis
What is the role of insulin on lipid meatabolism?
Insulin promotes lipid storage > incr Trig synthesis
- absorb fatty acids from circulating lipoproteins
What is the relationship of insulin on glycolysis on breakdown of Trig?
Inhibits this process, not in favor of fatty acids
- downregulate glycolysis
Relationship of insulin and proteolysis?
Insulin prevents proteolysis and promotes protein synth
- promotes energy storage vs release
What stimulates glucagon release?
Low insulin level
What kind of receptor does glucagon work with?
GPCR
