RICKETTSIA Flashcards

1
Q

RICKETTSIA KEY FACTS

A

OBLIGATE INTRACELLULAR
CULTURED IN YOLK SAC OF EMBRYONATED EGGS OR IN SELECT TISSUE CULTURE CELL LINES
STAINED BY ROMANOWKSKY
VECTOR BORNE- SPREAD BY TICKS, FLEAS, LICE, MOSQUITO
ZOONOTIC
INTERMEDIATE BETWEEN VIRUSES AND BACTERIA
EMERGING AND RE-EMERGING DISEASES
OBLIGATE INTRACELLULAR

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2
Q

RICKETTSIA TARGETS WHAT

A

ENDOTHELIUM

CAUSES VASCULITIS

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3
Q

RESERVOIRS OF RICKETTSIA

A

SMALL MAMMALS AND RODENTS

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4
Q

TRANSMISSION OF RICKETTSIA

A

ARTHROPOD BITE OR INHALATION OF ARTHROPOD FECES

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5
Q

RICKETTSIA CAUSES WHAT

A

SPOTTED FEVER

THYPUS

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6
Q

R. RICKETTSIA CAUSES

A

ROCKY MOUNTAIN SPOTTED FEVER

TICK VECTOR- DERMACENTOR

HOSTS- HUMANS, DOGS

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7
Q

R FELIS CAUSES

A

FLEA-BORNE SPOTTED FEVER

CAT FLEAS (CTENOCEPHALOIDES)

HUMAN HOST

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8
Q

R. TYMPHI CAUSES

A

MURINE TYPHUS

RAT AND CAT FLEAS
XENOPSYLLA AND CTENOCEPHALOIDES

HOST-HUMANS

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9
Q

ROCKY MOUNTAIN SPOTTED FEVER

A

SLYVATIC CYCLE IN WILDLIFE IMPORTANT- SMALL MAMMALS AND RODENTS
RANGE OF INFECTION DEPENDS ON TICK DISTRIBUTION

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10
Q

ROCKY MOUNTIAIN SPOTTED FEVER, R RICKETTSIA VIRULENCE FACTORS

A

PHOSPHOLIPASE AND PROTEASE DAMAGE MEMBRANES OF ENDOTHELIUM

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11
Q

R RICKETTSIA REPLICATES WHERE

A

CYTOPLASM AND NUCLEUS OF HOST CELL

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12
Q

R. RICKETTSIA CAUSES ENDOTHELIAL DAMAGE THAT INITIATES

A

VASCULITIS, PLATELET ACTIVATION, DIC, NECROSIS

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13
Q

R. RICKETSSIA- ROCKY MOUNTAIN SPOTTED FEVER CLINICAL SIGNS

A

FEVER DEPRESSION ANOREXIA SUBCUTANEOUS EDEMA PETECHIA IN MUCOSA MYALGIA

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14
Q

CAT FLEA TYPHUS LIKE ILLNESS - SPOTTED FEVER

A

R FELIS
CATS ARE ASYMPTOMATIC
VETOR CTENOCEPHALOIDES FELIS
SYLVATIC CYCLE =OPOSSUMS

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15
Q

MURINE TYPHUS

A

CAUSED BY RICKETTSIA TYPHI VECTOR C. FELIS AND XENOPHYLLA
RESERVOIRS- RODENTS, CATS, OPOSSUMS
ENDEMIC TO S.CALIFORNIA AND TEXAS
TRANSMISSION SCRATCHING OF INFECTED FLEA FECES INTO A BITE WOUND
HUMANS

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16
Q

R. RICKETTSIA IN DOGS CAUSES

A

THROMBOCYTOPENIA

SEROLOGY***** (BUT CANT TELL BW/ THYPHUS GROUP)

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17
Q

TREATMENT OF RICKETTISIA

A

DOXYCYCLINE
TETRACYCLINE
ENROFLAXIN
CHLORAMPHENICOL

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18
Q

ANAPLASMATACEAE

A

ANAPLASMA
EHRLICHIA
NEORICKETTSIA

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19
Q

ANAPLASMATACEAE IS EXTRACELLULAR OR INTRACELLULAR

A

INTRACELLULAR IN LEUKOCYTES, ERYTHROCYTES, ENDOTHELIAL CELLS, PLATELETS

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20
Q

WHAT VECTORS FOR ANAPLASMATACEAE

A

NEORICKETTSIA- TREMATODE

ANAPLASMA AND EHRLICHIA - TICKS

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21
Q

RESERVOIRS FOR ANAPLASMATACEAE

A

WILDLIFE

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22
Q

ANAPLASMATACEAE KEY POINTS

A

OBLIGATE INTRACELLULAR
LACK A GLYCOLYSIS CYCLE
LACK A CELL WELL SENSITIVE TO MECH STRESS
INHABIT CELL MEMBRANE DERIVED VACUOULES IN HEMATOPOETIC CELLS OF MAMMALS
FORM MORULA- CLUSTERS

23
Q

EHRLICHIA CANIS

A

DOGS
CANINE MONOCYTOTROPHIC EHRLICHIOSIS
MONOCYTES

24
Q

EHRLICHIA CHAFFEENIS

A

HUMAN MONOCYTOTROPHIC EHRLICHIOSIS

HUMANS, DOGS, GOATS

25
Q

EHRLICHIA EWINGII

A

INFECTS DOGS AND HUMANS

INFECTS GRANULOCYTES MAINLY NEUTROPHILS

26
Q

ANOPLASMA PHAGOCYTOPHILUM

A

INFECTS GRANULOCYTES MAINLY NEUTROPHILS

DOGS, CATS, HUMANS, HORSES, RUMINANTS AND LLAMAS

27
Q

ANAPLASMA PLATYS

A

INFECTS PLATELETS
DOGS
NOT ZOONOTIC

28
Q

ANAPLASMA PHAGOCYTOPHILUM RESERVOIRS

A

SMALL MAMMALS AND DEER

BIRDS ARE AMPLIFIERS

29
Q

ANAPLASMA PHAGOCYTOPHILUM VECTOR

A

IXODES TICKS

30
Q

GRANULOCYTIC ANAPLASMOSIS PATHOGENESIS

A
APOPTOSIS INHIBITION 
EVASION OF IMMUNE SYSTEM 
MULTIPLICATION
FORMULATION OF MORULA 
 RELEASE 
IMPAIRMENT OF PHAGOCYTOSIS AND NEUTROPHILS
31
Q

ANAPLASMA PHAGOCYTOPHILUM CAUSES ____ IN THE BLOOD

A

THROMBOCYTOPENIA

32
Q

CLINICAL SIGNS OF ANAPLASMA PHAGOCYTOPHILUM

A

FEVER, LETHARGY, MUSCULOSKELETAL PAIN

33
Q

DOES ANAPLASMA PHAGOCYTOPHILUM REQUIRE TREATMENT

A

NO IT IS SELF LIMITING

34
Q

WHAT DOES ANAPLASMA PHAGOCYTOPHILUM CAUSE IN HORSES ?

A

MILD EDEMA IN LIMBS, ATAXIA, DIC

35
Q

CANINE CYCIC THROMBOCYTOPENIA

A

ANAPLASMA PLATYS

36
Q

ACUTE INFECTIONS OF ANAPLASMA PLATYS

A

FEVER, PETECHIA, ECCYMOSIS

THROMBOCYTOPENIA CYCLIC !!!!!! DUE TO MULTIPLICATION CYCLES OF BACTERIA

37
Q

BOVINE ANAPLASMOSIS

A

ANAPLASMA MARGINALE

BACTERIA IN ERYTHROCYTES (MARGINALLY)

38
Q

YOUNGER CATTLE IN ENDEMIC AREAS GET SEVERE ANAPLASMOSIS T/F

A

FALSE THEY GET AN IMMUNE RESPONSE

CARRIER STATE

39
Q

NAIVE ADULTS GET SEVERE DISEASE DESCRIBE

A

ERYTHROCYTES RUPTURE, ICTERUS, ANEMIA
STRESS IS TRIGGER OF CLINICAL SIGNS
SEPARATE INF ANIMALS
OXYTETRACYCLINE

40
Q

CANINE MONOCYTIC EHRLICHIOSIS

A

EHRLICHIA CANIS

41
Q

EHRLICHIA CANIS VECTOR

A

RHIPHICEPHALUS SANGUINEUS

42
Q

ECHLICHIA CANIS RESERVOIRS

A

COYOTE, FOX, JACKAL, DOMESTIC DOGS

43
Q

EHRLICHIA CANIS PATHOGENESIS

A

ADHERENCE TO INVADE CELLS
REPLICATION IN VACUOLES TO EVADE IMMUNE SYSTEM
ABSENCE OF LPS ALLOW SURVIVAL IN HOST
IMMUNE AND INFLAMMATORY RESPONSE
THROMBOCYTOPENIA- PLATELET CONSUMPTION, DECREASED PLATELET HALF LIFE, IMMUNE MEDIATED DESTRUCTION
PANCYTOPENIA- BONE MARROW SUPPRESSION
HYPERGLOBULINEMIA

44
Q

CANINE MONOCYTIC EHRLICHIOSIS PHASES

A

ACUTE FEVER, THROMBOCYTOPENIA LASTS 4 WEEKS, MORULAS IN THE BLOOD SMEAR
SUBCLINICAL INFECTION FEVER, THROMBOCYTOPENIA, ANEMIA FOR MONTHS TO YEARS
CHRONIC FEVER WIDESPREAD PETECHIA, EDEMA, SUPPRESSED BONE MARROW- DEATH

45
Q

ACUTE OR CHRONIC PHASE SHARE THESE CLINICAL SIGNS

A

LYMPHADENOPATHY, SPLENOMEGALY, NASAL BLEEDING

46
Q

DIAGNOSIS OF EHRLICHIA AND ANAPLASMA

A

TICK EXPOSURE, CLINICAL SIGNS, BLOOD SMEAR, TISSUE ASPIRATES SPLEEN BONE MARROW LN, SEROLOGY GOOD FOR CHRONIC, PCR PREFERRED METHOD ***

47
Q

NEORICKETTSIA VECTOR AND RESERVOIR

A

VECTOR- TREMATODE
RESERVOIR- SNAIL
RESERVOIR- WATER INSECTS - INGEST WHILE DRINKING WATER

48
Q

NEORICKETTSIA RISTCII

A

EQUINE MONOCYTOTROPHIC EHRLICHIOSIS

POTOMAC HORSE FEVER

49
Q

NEORICKETTSIA HELMINTHOECA

A

SALMON POISONING DISEASE IN DOGS

50
Q

POTOMAC HORSE FEVER- NEORICKETTSIA RISTICII CLINCIAL SIGNS

A

FEVER, DIARRHEA, COLIC, ANOREXIA, LEUKOPENIA, LAMINITIS, ABORTION, HEMORRHAGIC ENTEROCOLITIS

51
Q

NEORICKETTSIA RISTICII INFECTS WHAT CELLS

A

ENTEROCYTES AND MONOCYTES

52
Q

DIAGNOSIS OF NEORICKETTSIA RISTICII

A

PCR OF BLOOD OR FECES

53
Q

TREATMENT OF NEORICKETTSIA RISTICII

A

EARLY DIAGNOSIS IS KEY
TREAT WITH OXYTETRACYCLINE
MINIMIZE INSECT INGESTION TURN OFF BARN LIGHTS AT NIGHT

54
Q

SALMON POISONING DISEASE

A

NEORICKETTSIA HELMINTHOECA
FEVER, DEPRESSION, DEHYDRATION, ANOREXIA, VOMITING, HEMORRHAGIC DIARRHEA, DEATH WITHOUT TREATMENT
TETRACYCLINE AND PRAZIQUANTEL