RICKETTSIA Flashcards
RICKETTSIA KEY FACTS
OBLIGATE INTRACELLULAR
CULTURED IN YOLK SAC OF EMBRYONATED EGGS OR IN SELECT TISSUE CULTURE CELL LINES
STAINED BY ROMANOWKSKY
VECTOR BORNE- SPREAD BY TICKS, FLEAS, LICE, MOSQUITO
ZOONOTIC
INTERMEDIATE BETWEEN VIRUSES AND BACTERIA
EMERGING AND RE-EMERGING DISEASES
OBLIGATE INTRACELLULAR
RICKETTSIA TARGETS WHAT
ENDOTHELIUM
CAUSES VASCULITIS
RESERVOIRS OF RICKETTSIA
SMALL MAMMALS AND RODENTS
TRANSMISSION OF RICKETTSIA
ARTHROPOD BITE OR INHALATION OF ARTHROPOD FECES
RICKETTSIA CAUSES WHAT
SPOTTED FEVER
THYPUS
R. RICKETTSIA CAUSES
ROCKY MOUNTAIN SPOTTED FEVER
TICK VECTOR- DERMACENTOR
HOSTS- HUMANS, DOGS
R FELIS CAUSES
FLEA-BORNE SPOTTED FEVER
CAT FLEAS (CTENOCEPHALOIDES)
HUMAN HOST
R. TYMPHI CAUSES
MURINE TYPHUS
RAT AND CAT FLEAS
XENOPSYLLA AND CTENOCEPHALOIDES
HOST-HUMANS
ROCKY MOUNTAIN SPOTTED FEVER
SLYVATIC CYCLE IN WILDLIFE IMPORTANT- SMALL MAMMALS AND RODENTS
RANGE OF INFECTION DEPENDS ON TICK DISTRIBUTION
ROCKY MOUNTIAIN SPOTTED FEVER, R RICKETTSIA VIRULENCE FACTORS
PHOSPHOLIPASE AND PROTEASE DAMAGE MEMBRANES OF ENDOTHELIUM
R RICKETTSIA REPLICATES WHERE
CYTOPLASM AND NUCLEUS OF HOST CELL
R. RICKETTSIA CAUSES ENDOTHELIAL DAMAGE THAT INITIATES
VASCULITIS, PLATELET ACTIVATION, DIC, NECROSIS
R. RICKETSSIA- ROCKY MOUNTAIN SPOTTED FEVER CLINICAL SIGNS
FEVER DEPRESSION ANOREXIA SUBCUTANEOUS EDEMA PETECHIA IN MUCOSA MYALGIA
CAT FLEA TYPHUS LIKE ILLNESS - SPOTTED FEVER
R FELIS
CATS ARE ASYMPTOMATIC
VETOR CTENOCEPHALOIDES FELIS
SYLVATIC CYCLE =OPOSSUMS
MURINE TYPHUS
CAUSED BY RICKETTSIA TYPHI VECTOR C. FELIS AND XENOPHYLLA
RESERVOIRS- RODENTS, CATS, OPOSSUMS
ENDEMIC TO S.CALIFORNIA AND TEXAS
TRANSMISSION SCRATCHING OF INFECTED FLEA FECES INTO A BITE WOUND
HUMANS
R. RICKETTSIA IN DOGS CAUSES
THROMBOCYTOPENIA
SEROLOGY***** (BUT CANT TELL BW/ THYPHUS GROUP)
TREATMENT OF RICKETTISIA
DOXYCYCLINE
TETRACYCLINE
ENROFLAXIN
CHLORAMPHENICOL
ANAPLASMATACEAE
ANAPLASMA
EHRLICHIA
NEORICKETTSIA
ANAPLASMATACEAE IS EXTRACELLULAR OR INTRACELLULAR
INTRACELLULAR IN LEUKOCYTES, ERYTHROCYTES, ENDOTHELIAL CELLS, PLATELETS
WHAT VECTORS FOR ANAPLASMATACEAE
NEORICKETTSIA- TREMATODE
ANAPLASMA AND EHRLICHIA - TICKS
RESERVOIRS FOR ANAPLASMATACEAE
WILDLIFE
ANAPLASMATACEAE KEY POINTS
OBLIGATE INTRACELLULAR
LACK A GLYCOLYSIS CYCLE
LACK A CELL WELL SENSITIVE TO MECH STRESS
INHABIT CELL MEMBRANE DERIVED VACUOULES IN HEMATOPOETIC CELLS OF MAMMALS
FORM MORULA- CLUSTERS
EHRLICHIA CANIS
DOGS
CANINE MONOCYTOTROPHIC EHRLICHIOSIS
MONOCYTES
EHRLICHIA CHAFFEENIS
HUMAN MONOCYTOTROPHIC EHRLICHIOSIS
HUMANS, DOGS, GOATS
EHRLICHIA EWINGII
INFECTS DOGS AND HUMANS
INFECTS GRANULOCYTES MAINLY NEUTROPHILS
ANOPLASMA PHAGOCYTOPHILUM
INFECTS GRANULOCYTES MAINLY NEUTROPHILS
DOGS, CATS, HUMANS, HORSES, RUMINANTS AND LLAMAS
ANAPLASMA PLATYS
INFECTS PLATELETS
DOGS
NOT ZOONOTIC
ANAPLASMA PHAGOCYTOPHILUM RESERVOIRS
SMALL MAMMALS AND DEER
BIRDS ARE AMPLIFIERS
ANAPLASMA PHAGOCYTOPHILUM VECTOR
IXODES TICKS
GRANULOCYTIC ANAPLASMOSIS PATHOGENESIS
APOPTOSIS INHIBITION EVASION OF IMMUNE SYSTEM MULTIPLICATION FORMULATION OF MORULA RELEASE IMPAIRMENT OF PHAGOCYTOSIS AND NEUTROPHILS
ANAPLASMA PHAGOCYTOPHILUM CAUSES ____ IN THE BLOOD
THROMBOCYTOPENIA
CLINICAL SIGNS OF ANAPLASMA PHAGOCYTOPHILUM
FEVER, LETHARGY, MUSCULOSKELETAL PAIN
DOES ANAPLASMA PHAGOCYTOPHILUM REQUIRE TREATMENT
NO IT IS SELF LIMITING
WHAT DOES ANAPLASMA PHAGOCYTOPHILUM CAUSE IN HORSES ?
MILD EDEMA IN LIMBS, ATAXIA, DIC
CANINE CYCIC THROMBOCYTOPENIA
ANAPLASMA PLATYS
ACUTE INFECTIONS OF ANAPLASMA PLATYS
FEVER, PETECHIA, ECCYMOSIS
THROMBOCYTOPENIA CYCLIC !!!!!! DUE TO MULTIPLICATION CYCLES OF BACTERIA
BOVINE ANAPLASMOSIS
ANAPLASMA MARGINALE
BACTERIA IN ERYTHROCYTES (MARGINALLY)
YOUNGER CATTLE IN ENDEMIC AREAS GET SEVERE ANAPLASMOSIS T/F
FALSE THEY GET AN IMMUNE RESPONSE
CARRIER STATE
NAIVE ADULTS GET SEVERE DISEASE DESCRIBE
ERYTHROCYTES RUPTURE, ICTERUS, ANEMIA
STRESS IS TRIGGER OF CLINICAL SIGNS
SEPARATE INF ANIMALS
OXYTETRACYCLINE
CANINE MONOCYTIC EHRLICHIOSIS
EHRLICHIA CANIS
EHRLICHIA CANIS VECTOR
RHIPHICEPHALUS SANGUINEUS
ECHLICHIA CANIS RESERVOIRS
COYOTE, FOX, JACKAL, DOMESTIC DOGS
EHRLICHIA CANIS PATHOGENESIS
ADHERENCE TO INVADE CELLS
REPLICATION IN VACUOLES TO EVADE IMMUNE SYSTEM
ABSENCE OF LPS ALLOW SURVIVAL IN HOST
IMMUNE AND INFLAMMATORY RESPONSE
THROMBOCYTOPENIA- PLATELET CONSUMPTION, DECREASED PLATELET HALF LIFE, IMMUNE MEDIATED DESTRUCTION
PANCYTOPENIA- BONE MARROW SUPPRESSION
HYPERGLOBULINEMIA
CANINE MONOCYTIC EHRLICHIOSIS PHASES
ACUTE FEVER, THROMBOCYTOPENIA LASTS 4 WEEKS, MORULAS IN THE BLOOD SMEAR
SUBCLINICAL INFECTION FEVER, THROMBOCYTOPENIA, ANEMIA FOR MONTHS TO YEARS
CHRONIC FEVER WIDESPREAD PETECHIA, EDEMA, SUPPRESSED BONE MARROW- DEATH
ACUTE OR CHRONIC PHASE SHARE THESE CLINICAL SIGNS
LYMPHADENOPATHY, SPLENOMEGALY, NASAL BLEEDING
DIAGNOSIS OF EHRLICHIA AND ANAPLASMA
TICK EXPOSURE, CLINICAL SIGNS, BLOOD SMEAR, TISSUE ASPIRATES SPLEEN BONE MARROW LN, SEROLOGY GOOD FOR CHRONIC, PCR PREFERRED METHOD ***
NEORICKETTSIA VECTOR AND RESERVOIR
VECTOR- TREMATODE
RESERVOIR- SNAIL
RESERVOIR- WATER INSECTS - INGEST WHILE DRINKING WATER
NEORICKETTSIA RISTCII
EQUINE MONOCYTOTROPHIC EHRLICHIOSIS
POTOMAC HORSE FEVER
NEORICKETTSIA HELMINTHOECA
SALMON POISONING DISEASE IN DOGS
POTOMAC HORSE FEVER- NEORICKETTSIA RISTICII CLINCIAL SIGNS
FEVER, DIARRHEA, COLIC, ANOREXIA, LEUKOPENIA, LAMINITIS, ABORTION, HEMORRHAGIC ENTEROCOLITIS
NEORICKETTSIA RISTICII INFECTS WHAT CELLS
ENTEROCYTES AND MONOCYTES
DIAGNOSIS OF NEORICKETTSIA RISTICII
PCR OF BLOOD OR FECES
TREATMENT OF NEORICKETTSIA RISTICII
EARLY DIAGNOSIS IS KEY
TREAT WITH OXYTETRACYCLINE
MINIMIZE INSECT INGESTION TURN OFF BARN LIGHTS AT NIGHT
SALMON POISONING DISEASE
NEORICKETTSIA HELMINTHOECA
FEVER, DEPRESSION, DEHYDRATION, ANOREXIA, VOMITING, HEMORRHAGIC DIARRHEA, DEATH WITHOUT TREATMENT
TETRACYCLINE AND PRAZIQUANTEL
