MANNHEMIA Flashcards
MANNHEMIA HEMOLYTICA IS ____
OBLIGATE SYMBIOTIC, FACULTATIVE PATHOGENIC IN RUMINANTS
WITH LOW ENVT RESISTANCE
MANNHEMIA HEMOLYTIC VIRULENCE FACTORS
LEUKOTOXIN- RTX FAMILY- HEMOLYSIS TRANSFERRIN BINDING PROTEINS ENDOTOXINS-LPS CAPSULE-ANTIPHAGOCYTOSIS FIMBRIAE
LEUKOTOXIN
LOW DOSE- OXIDATIVE METABOLISM OF NEUTROPHILS AND MACROPHAGES
HIGH DOSE- LYSIS OF PHAGOCYTES
ONLY EFFECTIVE IN SHEEP AND CATTLE
STRONGLY ANTIGENIC
WHERE IS M. HEMOLYTICA FOUND COMMENSALLY IN SHEEP?
NOSE AND TONSILS
ALL SEROTYPES
WHERE IS M HEMOLYTICA FOUND COMMENSALLY IN BOVIDS?
NASOPHARYNX AND TONSILS
SEROTYPES 1,2,6
BACTERIA BRONCHOPNEUMONIA IN CALVES
ENVT- REGROUPING ANIMALS (KINDERGARTEN FOR COWS)
VIRAL INF
BACTERIAL INF
WHAT DOES M HEMOLTYICA CAUSE
FIBRINOUS NECROTIC BRONCHO PNEUMONIA GENERAL SYMPTOMS- FEVER, ANOREXIA RESPIRATORY DISTRESS SEROFIBRINOUS PLEURITIS WELL DEFINED PNEUMONIA ZONES IN LUNGS
ENDOGENIC INFECTION
STRESS-> MULTIPLICATION IN NASOPHARYNX
EXOGENIC INFECTION
EXCRETION OF MH IN HIGH NUMBERS OTHER ANIMALS GET COLONIZED (AEROSOL, CLOSE CONTACT)
M HEMOLYTICA VACCINE SHOULD CONTAIN
LEUKOTOXIN, SURFACE ANTIGENS, TRANSFERRIN BINDING PROTEINS
IMMUNITY AGAINST M. HEMOLYTICA IS
MAINLY ANTIBODY MEDIATED
DIAGNOSIS M HEMOLYTICA
BACTERIAL CULTURE FROM LUNGS, BRONCHOALVEOLAR LAVAGE, NOSE
GET TO LAB FAST! LITTLE ENVT RESISTANCE
TREATMENT AND PREVENTION M HEMOLYTICA
VENTILATION, THERMOREGULATION, FEED LOWER ENERGY FEED- STOMACH FERMENTATION, VACCINATION, ABX
SHIPPING FEVER - WHAT 2 PATHOGENS
P. MULTOCIDA
M. HEMOLYTICA