BORDETELLA Flashcards
BORDETELLA BRONCHISEPTA IS
OBLIGATE SYMBIOTIC. FACULTATIVE PATHOGENIC.
BORDETELLA BROCHISEPTA HAS AFFINITY FOR
CILIATED RESPIRATORY EPITHELIUM
B. BRONCHISEPTA INFECTS WHAT AGE AND HOST
YOUNG PIGS.
WHAT DOES B. BRONCHISEPTA CAUSE. IN YOUNG. PIGS
NONPROGRESSIVE ATROPHIC RHINITIS, PNEUMONIC BORDETELLOSIS. (<1WK OLD PRIMARY;»_space;>1WK OLD SECONDARY INFECTION). PROGRESSIVE ATROPHIC RHINITIS (IN COMBINATION WITH PASTEURELLA MULTOCIDA)
BORDETELLA. VIRULENCE. FACTORS
ADHESINS (3). TOXINS. (4) LPS SIDEROPHORES LACTOFERRIN TRANSFERRIN BINDING PROTEIN. BVG REGULON BIOFILMS
WHAT IS BVG REGULON?
REGULATES EXPRESSION. BETWEEN VIRULENT AND NONVIRULENT. LOW TEMPERATURES = HIGHER VIRULENCE
WHAT ARE THE THREE ADHESION. FACTORS OF BORDETELLA
FILAMENTOUS HEMAGGLUTIN (MOST IMPORTANT- ATTACHMENT OF OUTER MEMBRANE TO MACROPHAGES), PERTACTIN, FIMBRIAE.
WHAT ARE THE 4 TOXINS OF. BORDETELLA AND THEIR FUNCTION.
HEMOLYSIN- PORE FORMING, INHIBITION OF NEUTROPHILS
DERMONECROTIC TOXIN- DAMAGE TO NASAL TISSUE AND OSTEOBLASTS
OSTEOTOXIN- TOXIC TO OSTEOBLASTS
TRACHEAL CYTOTOXIN- DAMAGES CILIATED RESPIRATORY EPITHELIUM
B. BRONCHISEPTA TRANSMISSION
AEROSOL, SOW TO PIGLET
PREDISPOSING FACTORS OF BORDETELLA BRONCHISEPTA
INFECTION PRESSURE, OVERCROWDING, STRESS, DUST, VENTILATION
HOW TO DIAGNOSE B. BRONCHISEPTA
CULTURE WITH BLOOD AGAR
PCR- SAMPLE. NOSE AND TONSILS
SYMPTOMS
HOW TO TREAT B. BRONCHISEPTA
HYGIENE, VAX SOW AND PIGLETS, ABX SULFONAMIDES
NONPRODUCTIVE ATROPHIC RHINITIS
DAMAGE NASAL MUCOSA
MUCOUS PRODUCTION
DERMONECROTIC TOXIN
PNEUMONIC BORDETELLOSIS
COUGHING, DYSAPNEA, NO FEVER, HIGH MORBIDITY
PURULENT. BRONCHIOLITIS AND ALVEOLITIS.
LESIONS IN LUNGS ARE DRY, BROWN.
<1WK OLD PRIMARY INF. >1WKOLD SECONDARY INF
PROGRESSIVE ATROPHIC RHINITIS
LOSS OF NASAL CONCHAE
IN COMBINATION WITH. PASTEURELLA MULTOCIDA
BB EFFECTS OSTEOBLASTS. PM EFFECTS OSTEOCLASTS
BB COLONIZES FIRST PM INFECTS SECOND