Rheumatology Flashcards
Anti-CCP AB
Rheumatoid Arthritis
Anti-dsDNA AB
SLE
May fluctuate with diease activity
Anti-RNP
Mixed Connective Tissue Disease
Anti-Centromere
Limited Systemic Sclerosis
Anti-Scl 70
Diffuse Systemic Sclerosis
Anti-Ro
Sjogren’s Syndrome
Anti-La
Sjogren’s Syndrome
Anti-Jo1
Myositis
Anti-Sm
SLE
Anti-cardiolipin AB
Anti-Phospholipid Syndrome
cANCA/anti-PR3
GPA
pANCA/anti-MPO
EGPA
Microscopic polyangitis
C3 and C4
Low in immune complex vasculitis especially lupus nephritis
Management of Paget’s Disease
Bisphosphonates
Behcet’s Syndrome
= oral ulcers, genital ulcers, uveitits
Associated with thrombophlebitis
Drug-Induced Lupus
Drug associated with (TB)
Isoniazid
Felty’s Syndrome
= splenomegaly, RA and neutropaenia
Acute VS Chronic in Rheumatology
Acute < 6 weeks
Co-prescription with allopurinol
Why?
NSAIDs/colchicine
Covers any flares as a result from fluctuating uric acid levels
Alternative investigation in suspected temporal arteritis
Ultrasound
See thickening and narrowing of the temporal artery
Management of polymyositis
1mg/kg steroids
Usually need an immunosuppressant as well
Antibodies seen in drug-induced lupus
Anti-histone AB
Management of polymyositis
1mg/kg of oral steroids
Cardiac Associations with Ankylosing Spondylitis (2)
Heart Block
= AV dissociation on ECG
Aortic Regurgitation
= see LVH on ECG (deep S1 in V1, tall R in V5)
Eye complication seen with HCQ use
Retinitis
Haematology complication seen with azathioprine (small risk)
Lymphoma
