Rheumatology Flashcards
Common symptoms people present to rheumatology with
pain stiffness swelling functional impairment systemic symptoms
Signs of RA
tenderness swelling restricted movements heat and redness systemic features
List some rheumatic diseases
RA connective tissue diseases sero negative arthritis bone disease crystal arthritis systemic vasculitis
Functions of synovium
maintain intact tissue surface
lubrication of cartilage
control of synovial fluid volume and composition - hyaluronic acid and lubricin
nutrition of chondrocytes within joints
Describe the rheumatoid joint
inflamed synovium and tendon sheath
erosion into corner of the bone and thinning of cartilage
Define RA
chronic, symmetric, autoimmune, inflammatory
small joints in hands and feet
pannus
rheumatoid synovitis
inflammatory cell infiltration, synoviocyte proliferation and neoangiogenesis
What is found in synovial fluid in acute RA flares?
neutrophils
Autoantibodies
RF and ACPA
What can the autoantibodies recognise?
joint eg type 2 collagen or systemic antigens
How can autoantibodies contribute to inflammation?
activation of complement
What does RF do?
autoantibody to self IgG Fc
does sero negative or positive RA have a better prognosis?
negative
Genes in RA
susceptibility and severity
monozygotic twins: 15-30%
HLA-DR4, PTPN22
promote autoimmunity and molecular mimicry
Environmental factors
smoking and bronchial stress
infectious agents eg viruses and periodontal disease
What happens after repeated insults in a susceptible person?
form immune complexes and RF
altered citrullination of proteins and breakdown of tolerance with resulting ACPA response
citrullination
converting the amino acid arginine to citrulline
Very briefly describe the synovitis with inflammatory cells
CD4+ T cells, macrophages and B cells
local hypoxia and cytokines –> neoangiogenesis
insufficient lymphangiogenesis for clearance