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MRCP > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Calcification of the triangular fibrocartilage suggests chondrocalcinosis - which condition is this associated?

A

Pseudogout

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2
Q

most common cause of osteomyelitis (bacteria)

A

staph aureus

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3
Q

Rheumatoid factor is an Ig? antibody against Ig?

A

IgM Ab against IgG

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4
Q

Rheumatoid arthritis X ray findings:

a) early (3)
b) late (2)

A

a) Early
- loss of joint space
juxta-articular osteoporosis
soft-tissue swelling

b) Late
- periarticular erosions
- subluxation

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5
Q

Patients with aspirin allergy/ hypersensitivity should avoid what medication?

A

sulphasalazine

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6
Q

adult onset Stills management (3)

A
  1. NSAIDS
  2. Steroids
  3. Methotrexate, IL-1 inhibitor (Anakinra), TNF a
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7
Q

Mutation in Collagen type 1

A

osteogenesis imperfecta

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8
Q

Mutation in Collagen type 2 - give rise to

A

Chondrodysplasia

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9
Q

Mutation in collagen type 3 leads to

A

Elhers Danlos

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10
Q

Mutation in collagen type 4

A

Goodpastures + Alports

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11
Q

severe side effect of hydroxychoroquine (often used in SLE)

A

retinopathy due to ocular toxicity of hydrxychloroquine

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12
Q

Ank spon is associated with (6)

A
  • Anterior uveitis
  • AV node block
  • Achilles tendonitis
  • Apical fibrosis
  • Amyloidosis
  • Aortic regurgitation
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13
Q

Cubital tunnel syndrome is compression of which nerve?

A

ulna - paraesthesia of 4/5th fingers

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14
Q

Raynauds phenomena management (2)

A
  1. CCB - nifedipine

2. iv prostocycline (epoprostenol)

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15
Q

TNF a inhibitors can lead to reactivation of what condition

A

TB

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16
Q

Familial Mediterranean fever associated with (4)

A

Peritonitis - abdo pain
Pericarditis - chest pain
Synovitis - joint pain
fever

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17
Q

bisphosphonates mechanism

A

inhibits osteoclasts

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18
Q

pseudogout risk factors (6)

A 
haemachromotosis
Acromegaly
wilsons
hypomag
hypophos
hyper PTH
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19
Q

methotrexate mechanism

A

inhibits dihydrofolate reductase

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20
Q

lateral epicondylitis test (movement)

A

wrist extension/ supination whilst elbow fully extended exacerbates the pain

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21
Q

Limited (central) cutaneous systemic sclerosis associated with which antibody

A

anti-centromere

22
Q

Denosumab (used for osteoporosis) mechanism

A

Denosumab is RANKL inhibitor preventing osteoclast development

23
Q

Ottawa rules - Reasons for X ray in Ankle pain

A
  • any malleolar zone pain
  • bone tenderness lat mal
  • bone tenderness med mal
  • inability to walk after injury and on examination
24
Q

Ank spon management (3)

A

1 - Exercise + NSAID

  1. DMARD (sulfasalazine)
  2. TNF a (eg etanercept) if persistence
25
Q

rheumatoid arthritis management

A
  1. DMARD (monotherapy) + steroid

2. TNF a - if 2 failed DMARDs including methotrexate)

26
Q

mixed connective tissue disease antibody is…

A

Anti-ribonuclear protein

27
Q

Major target of pANCA is…

A

myeloperoxidase - neutrophil protein whose primary role is the generation of oxygen free radicals.

28
Q

X ray findings of ank spon (4)

A
  • syndesmophytes - ossification of outer fibres of annulius fibrosis
  • squaring of lumbar vertebrae
  • sacroillitis - subchondral erosions, sclerosis
  • “bamboo spine” - late and uncommon
29
Q

Drugs that cause drug induced lupus

A

Most common - procainamide, hydralazine

Less common - Isoniazid, phenytoin, minocycline

30
Q

osteoporosis in men, you should test for…

A

testosterone - hypogonadism is highly linked with osteoporosis in men

31
Q

Dermatomyositis associated with which antibody

A

Anti-Jo 1

32
Q

methotrexate mechanism

A

inhibits dihydrofolate reductase

33
Q

In Marfans, there is a defect of…

A

the Glycoprotein structure that normally wraps around elastin

34
Q

Most common cause of death in systemic sclerosis (crest) (2)

A

RESP!
Interstitial lung disaese
Pul HTN

35
Q

Adhesive capsulitis Feature (1)

A

External rotation impairment (shoulder)

36
Q

Reactive arthritis
features (3)
cause (2 types)
synovial fluid (1)

A

uveitis, urethritis, arthritis (cant see, pee, knee)
chlamydia (sti related)
Shigella, campylobater, salmonella (dysentry related)
nil synovial fluid organism

37
Q

Familial Mediterranean Fever Mx

A

Colchicine

38
Q

Dermatomyositis antibodies (2)

A

ANA - most common

Anti-Mi2 - most specific (less common)

39
Q

SLE antibodies (3)

A

ANA most sensitive

anti-Sm & anti-dsDNA most specific

40
Q

Sjogren’s associated with what malignancy

A

Non-hodgkins lymphoma

41
Q

Hydroxychloroquine main side effect

A

retinopathy

42
Q

Osteomalacia features

A 
bone pain
proximal myopathy (waddling gait)
Vit D deficiency (indoors all the time?)
43
Q

Anti Jo 1 association

A

Polymyositis

44
Q

Anti scl 70

A

diffuse cutaneous systemic sclerosis

45
Q

anti centromere

A

limited cutaneous systemic sclerosis

46
Q

Behcets features (3)

A

oral ulcer
genital ulcer
anterior uveitis
(meningitis, DVT)

47
Q

Anti RNP (ribonuclear protein) association

A

mixed connective tissue disorder

47
Q

Anti RNP (ribonuclear protein) association

A

mixed connective tissue disorder

48
Q

De Quervains synovitis features

A

tender radial styloid process

49
Q

HLA B27 association

A

ank spon
reactive arthritis
ant uveitis

50
Q

Felty syndrome (3)

A

rheumatoid arthritis
splenomegaly
low white cell count

51
Q

Polymyositis antibody

A

anti-Jo1

MRCP (14 decks)

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