Endocrine

Question 1

Hypertension and HypoK (4)

Answer 1

Primary hyperaldosteronism (B/L adrenal hyperplasia, Adrenal Adenoma/ Conns)
Cushings
11-beta hydroxylase def
Liddles

Question 2

High uric acid associations

Answer 2

HTN
Hyperlipids
Metabolic syndrome

Question 3

Diagnostic for Cushing’s syndrome

Answer 3

low dose (overnight) dexamethasone suppression test

Question 4

Hashimoto associated with which type of cancer

Answer 4

thyroid lymphoma

Question 5

Which feature is specific to only Graves disease

Answer 5

exophthalmos

Question 6

subacute (De quervains) thyroiditis features (3)

Answer 6

tender goitre
thyrotoxicosis (initially)
post viral illness

Question 7

Impaired FASTING glucose pthophys

Answer 7

hepatic insulin resistance

Question 8

Impaired glucose tolerance pathophys

Answer 8

muscle insulin resistance

Question 9

Octreotide Mechanism of action

Answer 9

Somatostatin analogue - somatostatin directly inhibits GH release

Question 10

phaeochromocytoma dignostic test

Answer 10

24 hour urinary METANEPHRINES

Question 11

fibrates mechanism

Answer 11

Fibrates work through activating PPAR alpha receptors resulting in an increase in Lipoprotien lipase (LPL) activity reducing triglyceride levels

Question 12

Addisons diagnostic test

Answer 12

Short synacthen test

Question 13

insulinoma diagnostic test

Answer 13

supervised prolonged fasting

Question 14

sulphynurea hypoglycaemia - insulin + C peptide results

Answer 14

insulin high

c peptide high

Question 15

insulin induced hypoglycaemia - insulin + c peptide

Answer 15

insulin high

c peptide low

Question 16

Multiple Endocrine Neoplasia 1

a) features (3)
b) associations (3)
c) gene

Answer 16

a) Hypercalcaemia, galactorrhoea, peptic ulcer
b) HyperParathyroid, Pituitary, Pancreas (eg insulinoma)
c) MEN1 gene

Question 17

Multiple Endocrine Neoplasia 2a

a) features (nil)
b) associations (3)
c) gene

Answer 17

a) ?
b) Medullary thyroid Ca, Parathyroid, Phaeochromocytoma
C) RET oncogene

Question 18

Multiple Endocrine Neoplasia 2b

a) features
b) associations (1)
c) gene

Answer 18

a) Marfanoid habitas, neuromas
b) Phaeochromocytoma
c) RET oncogene

Question 19

Orlistat MOA

Answer 19

Pancreatic lipase inhibitor

Question 20

Urinary incontinence Mx - 1st/ 2nd line
urge incontinence:
stress incontinence:

Answer 20

urge incontinence: 1st bladder retraining, 2nd Oxybutynin

stress incontinence: 1st pelvic floor muscle training, 2nd Duloxetine

Question 21

Primary hyperparathyroidism Mx

Answer 21

parathyroidectomy (surgery)

Question 22

HRT complications (5)

Answer 22

breast Ca (increased with progestogen)
endometrial Ca (increased with oestrogen)
VTE (increased with progestogen)
Stroke
IHD