Rheum - antibodies (F)

Question 1

What is the auto-antibody associated with myasthenia gravis?

Answer 1

anti-ACh receptor

Question 2

What is the auto-antibody associated with Goodpasture syndrome?

Answer 2

anti-glomerular basement membrane

Question 3

Anti-B2 glycoprotein is the auto-antibody associated with what condition?

Answer 3

antiphospholipid syndrome

Question 4

What 2 antibodies can are associated with SLE and antiphospholipid syndrome?

Answer 4

1. anticardiolipin

2. lupus anticoagulant

Question 5

What 2 antibodies are only associated with SLE?

Answer 5

1. anti-dsDNA

2. anti-smith

Question 6

What 5 antibodies are associated with SLE?

Answer 6

1. anti-dsDNA
2. anti-smith
3. anticardiolipin
4. lupus anticoagulant
5. ANA (nonspecific)

Question 7

What antibody is associated with drug induced lupus?

Bonus: what drugs cause this condition?

Answer 7

anti-histone

Bonus: MC = isoniazid, hydralazine, procainamide

Question 8

What antibody is associated with limited scleroderma?

Answer 8

anti-centromere

Question 9

CREST syndrome is associated with positive ____ antibody

Answer 9

anti-centromere

Question 10

Anti-Scl-70 and anti-DNA topoisomerase 1 are 2 antibodies associated with which AI condition?

Answer 10

diffuse scleroderma

Question 11

What antibody is associated with pemphigus vulgaris?

Answer 11

anti-desmoglein

Question 12

What antibody is associated with bullous pemphigoid?

Answer 12

anti-hemidesmosome

longer name = deeper structure = tense blisters

Question 13

What 2 antibodies are associated with DM1?

Answer 13

1. anti-glutamic acid decarboxylase

2. islet cell cytoplasmic antibodies

Question 14

Anti-Jo-1 (anti-synthetase) is associated with what two conditions?

Answer 14

1. Dermatomyositis

2. Polymyositis

Question 15

Anti-Jo-1 is associated with dematomyositis and polymyositis. What condition is anti-Ro and anti-La assocaited with?

Answer 15

Sjrogen’s syndrome

Question 16

Dermatomyositis and polymyositis are associated with what antibodies in addition to anti-Jo-1?

Answer 16

1. anti-SRP

2. anti-helicase (anti-Mi-2)

Question 17

Anti-Ro and Anti-La are associated with Sjrogen’s syndrome. What are these antibodies alt. names?

Answer 17

anti-Ro = anti-SSA
anti-La = anti-SSB

Question 18

Anti-SSA and anti-SSB are associated with what condition?

Answer 18

Sjrogen’s syndrome

Question 19

What 3 antibodies are associated with hashimoto’s thyroiditis?

Answer 19

1. antimicrosomal
2. antithyroglubulin
3. antithyroidperoxidase

Question 20

Antimitochondrial is associated with what condition?

Answer 20

PBC

Question 21

Pernicious anemia is associated with what 2 antibodies?

Answer 21

1. antiparietal cell

2. anti-intrinsic factor

Question 22

What antibody is associated with primary membranous nephropathy?

Answer 22

antiphospholipase A2 receptor

Question 23

Anti-smooth muscle is associated with what condition?

Answer 23

AI hepatitis type 1

Question 24

Graves disease is associated with what antibody?

Answer 24

anti-TSH receptor

Question 25

Lambert-Eaton syndrome is associated with what antibody?

Answer 25

anti-presynaptic voltage-gated Ca channel

Question 26

Celiac disease is associated with which 2 antibodies?

Answer 26

1. IgA anti-tissue transglutaminase (IgA anti-TTG) | 2. IgA anti-endomysial

Question 27

Microscopic polyangiitis is associated with which antibody?

Answer 27

MPO-ANCA/p-ANCA

Question 28

Eosinophilic granulomatosis with polyangiitis is associated with which antibody? (Bonus: what was this condition's prev. name?)

Answer 28

MPO-ANCA/p-ANCA | Bonus: Churg-strauss syndrome

Question 29

Ulcerative colitis is associated with which antibody?

Answer 29

MPO-ANCA/p-ANCA

Question 30

PR3-ANCA/c-ANCA is associated with which condition?

Answer 30

Granulomatosis w/ polyangiitis (Wegener)

Question 31

MPO-ANCA/ p-ANCA is associated with which 3 conditions?

Answer 31

1. Microscopic polyangiitis 2. Eosinophilic granulomatosis w/ polyangiitis (Churg-strauss) 3. Ulcerative colitis

Question 32

What 2 antibodies are associated with RA and which is more specific?

Answer 32

1. Rheumatoid factor | 2. anti-cyclic citrullinated peptide (more specific)

Question 33

What is ANA?

Answer 33

antinuclear antibody = nonspecific screening antibody. often associated with SLE

Question 34

Mixed connective tissue disease is associated with what antibody?

Answer 34

Anti-U1 RNP (ribonucleoprotein)