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COMLEX Level 2CE > Rheum - antibodies (F) > Flashcards

Rheum - antibodies (F) Flashcards

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1
Q

What is the auto-antibody associated with myasthenia gravis?

A

anti-ACh receptor

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2
Q

What is the auto-antibody associated with Goodpasture syndrome?

A

anti-glomerular basement membrane

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3
Q

Anti-B2 glycoprotein is the auto-antibody associated with what condition?

A

antiphospholipid syndrome

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4
Q

What 2 antibodies can are associated with SLE and antiphospholipid syndrome?

A
  1. anticardiolipin

2. lupus anticoagulant

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5
Q

What 2 antibodies are only associated with SLE?

A
  1. anti-dsDNA

2. anti-smith

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6
Q

What 5 antibodies are associated with SLE?

A
  1. anti-dsDNA
  2. anti-smith
  3. anticardiolipin
  4. lupus anticoagulant
  5. ANA (nonspecific)
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7
Q

What antibody is associated with drug induced lupus?

Bonus: what drugs cause this condition?

A

anti-histone

Bonus: MC = isoniazid, hydralazine, procainamide

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8
Q

What antibody is associated with limited scleroderma?

A

anti-centromere

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9
Q

CREST syndrome is associated with positive ____ antibody

A

anti-centromere

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10
Q

Anti-Scl-70 and anti-DNA topoisomerase 1 are 2 antibodies associated with which AI condition?

A

diffuse scleroderma

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11
Q

What antibody is associated with pemphigus vulgaris?

A

anti-desmoglein

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12
Q

What antibody is associated with bullous pemphigoid?

A

anti-hemidesmosome

longer name = deeper structure = tense blisters

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13
Q

What 2 antibodies are associated with DM1?

A
  1. anti-glutamic acid decarboxylase

2. islet cell cytoplasmic antibodies

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14
Q

Anti-Jo-1 (anti-synthetase) is associated with what two conditions?

A
  1. Dermatomyositis

2. Polymyositis

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15
Q

Anti-Jo-1 is associated with dematomyositis and polymyositis. What condition is anti-Ro and anti-La assocaited with?

A

Sjrogen’s syndrome

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16
Q

Dermatomyositis and polymyositis are associated with what antibodies in addition to anti-Jo-1?

A
  1. anti-SRP

2. anti-helicase (anti-Mi-2)

17
Q

Anti-Ro and Anti-La are associated with Sjrogen’s syndrome. What are these antibodies alt. names?

A 
anti-Ro = anti-SSA
anti-La = anti-SSB
18
Q

Anti-SSA and anti-SSB are associated with what condition?

A

Sjrogen’s syndrome

19
Q

What 3 antibodies are associated with hashimoto’s thyroiditis?

A
  1. antimicrosomal
  2. antithyroglubulin
  3. antithyroidperoxidase
20
Q

Antimitochondrial is associated with what condition?

21
Q

Pernicious anemia is associated with what 2 antibodies?

A
  1. antiparietal cell

2. anti-intrinsic factor

22
Q

What antibody is associated with primary membranous nephropathy?

A

antiphospholipase A2 receptor

23
Q

Anti-smooth muscle is associated with what condition?

A

AI hepatitis type 1

24
Q

Graves disease is associated with what antibody?

A

anti-TSH receptor

25
Q

Lambert-Eaton syndrome is associated with what antibody?

A

anti-presynaptic voltage-gated Ca channel

26
Q

Celiac disease is associated with which 2 antibodies?

A
  1. IgA anti-tissue transglutaminase (IgA anti-TTG)

2. IgA anti-endomysial

27
Q

Microscopic polyangiitis is associated with which antibody?

A

MPO-ANCA/p-ANCA

28
Q

Eosinophilic granulomatosis with polyangiitis is associated with which antibody? (Bonus: what was this condition’s prev. name?)

A

MPO-ANCA/p-ANCA

Bonus: Churg-strauss syndrome

29
Q

Ulcerative colitis is associated with which antibody?

A

MPO-ANCA/p-ANCA

30
Q

PR3-ANCA/c-ANCA is associated with which condition?

A

Granulomatosis w/ polyangiitis (Wegener)

31
Q

MPO-ANCA/ p-ANCA is associated with which 3 conditions?

A
  1. Microscopic polyangiitis
  2. Eosinophilic granulomatosis w/ polyangiitis (Churg-strauss)
  3. Ulcerative colitis
32
Q

What 2 antibodies are associated with RA and which is more specific?

A
  1. Rheumatoid factor

2. anti-cyclic citrullinated peptide (more specific)

33
Q

What is ANA?

A

antinuclear antibody = nonspecific screening antibody. often associated with SLE

34
Q

Mixed connective tissue disease is associated with what antibody?

A

Anti-U1 RNP (ribonucleoprotein)

COMLEX Level 2CE (23 decks)

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