Rh System High's and Low's

Question 1

Partial DIIIa

Answer 1

DAK + (RH54)
Strong D epitope types as D+
Common in SCD patients; assoc. with varient RHCE*ces
Can make anti-D, c, or hrb

Question 2

Partial DIVa

Answer 2

Goa + (RH30)

Type as D+ common in blacks

Question 3

Partial DV

Answer 3

Dw (Rh23)

Question 4

Partial DVI

Answer 4

BARC (RH52)
FDA requires reagents to type as Rh neg at IS
6-10% of D positive people who make anti-D
Occurs in whites

Question 5

Partial DVII

Answer 5

TAR (RH40)
Type as D+
Occurs in Whites

Question 6

DFR

Answer 6

FPPT (RH50) positive

Question 7

DBT

Answer 7

Rn (RH32) positive
Occurs in blacks. Normal D gene w/ weak C and e
Can make anti-SEC (RH46)

Question 8

DHAR

Answer 8

FPTT (RH50) and RH33 positive
Formerly known as RoHAR; better called ceHAR.
Hybrid ce gene with no D gene present
Type as D+
Found in Germans

Question 9

Crawford

Answer 9

RH43
Present in blacks
No gene present; amino acid change results in a D like epitope that types as D+ with some reagents

Question 10

RH6

Answer 10

f = c in cis to e

present on Ro and r cells

Question 11

RH7

Answer 11

Ce = C in cis to e

Compound antigen present on R1 and r’ cells

Question 12

RH27

Answer 12

cE compound antigen

present and R2 and r” cells

Question 13

RH12

Answer 13

G antigen
Serine at 103 on D and CE gene
Anti-G reacts with any D or C positive cell

Question 14

RH51

Answer 14

MAR

High freq. negative in 0.2% Finns

Question 15

RH26

Answer 15

c like. Present on most c+ cells

antibody reacts with some c+ cells but not all

Question 16

RH39

Answer 16

C like high frequency

antibody reacts stronger with C+ cells

Question 17

RH18

Answer 17

Hr

High freq present in all except hrs-, Rh null, D–

Question 18

Rh19

Answer 18

hrs
e variant - allo anti-e in e positive people
can make anti-Hr (RH18)

Question 19

RH31

Answer 19

hrB
e variant. can make anti-HrB (seperate antibody)
weak anti-hrB can look like anti-C or Ce

Question 20

RH17

Answer 20

Hro
negative in D– and D** people who can make anti-RH17 when immunized
anti-pdl = auto antibody

Question 21

RH29

Answer 21

Total Rh
made by immunized Rh null phenotype
Anti-dl = auto antibody

Question 22

RH11

Answer 22

Ew
E variant found in German’s
Can make anti-E