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SBB > Ii > Flashcards

Ii Flashcards

1
Q

What Gene codes for I antigen

A

IGnT
B6-cetylglucosaminyltransferase that adds a GlcNAc to type 2 precursor chains
i is blood group collection 207

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2
Q

What chromosome is I gene located on?

A

Chromosome 6

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3
Q

i (adult) phenotype

A

w/o cataracts = I antigen not on RBC but still in tissues
w/ cataracts = no I antigen on RBC’s or Tissues
- occurs in Asiansq

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4
Q

What chain is i antigen on?

A

H2 chains - Type 2 precursor straight unbranched chains

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5
Q

What chain is I antigen on?

A

H3 and H4 chains - Type 2 precursor branched chains

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6
Q

How are ABH, Lewis, and P1 related to I structure?

A

I is the precursor for A, B, H, Lewis, and P1

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7
Q

Anti-I and -IH linked to ABO group?

A

Anti-I is formed in Group O

Anti-IH is formed in Group A

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8
Q

H antigen vs I antigen

A

The H antigen present the less I antigen
Except Group has Lots of I and H antigen
Cord cells have lots of H and very little i

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9
Q

Ii antigen charactersitics

A

I is poorly developed on cord cells and considered I negative and i positive
Enzymes enhance I expression
Resistant to DTT and EGA
Amt of I antigen present is variable

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10
Q

What age is I antigen fully developed

A

By 2 years of age

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11
Q

Where else is I found in body?

A

Amniotic fluid, hydatid cyst fluid, urine, saliva, human milk, leukocytes and plasma

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12
Q

Adult i phenotype

A

occurs 1 in 10,000
Recessive mutation that forms enzyme unable to form branched chains
Often make anti-I

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13
Q

Characteristics of i1 phenotype

A

most i and least I

Anti-I will react with i cord and i2, but not other i1 cells

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14
Q

Characteristics of i2 phenotype

A

Less i and most I

Anti-I reacts with i cord cells and not other i2 or i1 cells

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15
Q

Anti-I characteristics

A

found in nearly all sera if tested at 4C

Classically, Anti-I reacts with all adult cells and weakly with cord cells and adult i cells

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16
Q

Auto vs Allo anti-I

A

If enough autoantibody is attached to patients RBC’s then patient may type as I negative

17
Q

Anti-Lectin

A

Aplysia depilans

18
Q

Disease associated with anti-I

A

Mycoplasma pnuemoniae

19
Q

Disease associated with anti-i

A

Infectious mononucleosis (transient but POTENT)
Reticulosis
Alcoholic cirrhosis
Myeloid leukemia

20
Q

Anti-i characteristics

A

Rare antibody

stronger reaction with cord cells

21
Q

What are antibodies to compound antigens?

A

Specificity of antibody is not a mixture of antibodies but both antigens must be present for antibody to react
Ex) anti-IA will react with A cells with I

22
Q

Anti-I(f)

A

Anti-I(f) reacts with both adult and cord cells

Causes cold hemagglutinin disease

23
Q

Anti-I(D)

A

Most common form of anti-I
Much stronger reactions with Adult cells and very weak titer with cord cells and i adult cells
Found in adult i people
can be inhibited with human milk

24
Q

Anti-I(T)

A

T= transitional
Reacts with cord cells better than adult I and adult i cells
Found in Melanesians and Venezuelans

25
Q

Cold auto adsorption

A

Treat cells with ficin to enhance antibody binding

Time consuming, requires a lot of sample, and patient must not be recently transfused

26
Q

What is RESt?

A

Rabit Erythrocyte Stroma contains I and i antigens and can be used to adsorbed cold antibody
May also adsorb out anti-D, -E, and -K
Can’t be used for ABO typing because will adsorb out anti-B

27
Q

Characteristics of pathological auto anti-I in CHD?

A

Reacts at 32C and activates complement at 30-37C
Titer is > 500 at 4C and >128 at room temp
Will hemolyze enzyme treated cells at low pH
Antibody is typically monoclonal or idiopathic

28
Q

Characteristics of benign auto-I?

A

Reacts at <25C and activates Complement at <25C
Titer is < 64 at 4C and <16 at room temp
Antibody is polyclonal

29
Q

Pr antibodies

A

antibodies will NOT react with enzyme treated cells
React equally with Adult I, i, and cord cells
Isolated membrane SPG’s can neutralize antibodies
Suspected with enzyme treated cell fail to adsorb autoantibody

30
Q

Gd antibodies

A

IgM antibody reacts equally with adult I, i, and cord cells
Not destroyed by enzymes
Antigen is inactivated by neuraminidase

31
Q

Effect of Proteases and Neuraminid on I and i

A

I and i are enhanced

32
Q

Diseases and Ii concentration

A

Increased I and i is found in chronic hemolytic disorders and is a sign of stresses erythropoiesis

  • Thalassemia major
  • Hypoplastic anemia
  • CLL
  • Acute leukemia
  • Bombay phenotype
33
Q

I substance is found in the following

A

Urine, Human milk, Saliva

SBB (37 decks)

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