Revision Questions Flashcards
Name of cell present in Hodgkin’s lymphoma
Reed Sternberg
What CD markers are present on Reed Sternberg cells?
CD30
CD15
What translocation is present in Burkitt’s lymphoma?
8;14
What type of lymphoma is cyclin D1 positive?
Mantle cell
What are the CD markers in mantle cell lymphoma?
CD20
CD79
What translocation is present in mantle cell lymphoma?
11;14
Where does mycosis fungoides lymphoma present?
Skin
What markers are present in small cell lymphocytic lymphoma?
CD5
CD23
What gene is over expressed in follicular lymphoma?
BCL2
What CD marker is present in follicular lymphoma?
CD10
What neoplasms cause enlargement of the thymus?
Thymomas
Lymphomas
Germ cell tumours
Carcinoid tumours
What diseases are thymomas associated with?
Myasthenia gravis
RH
Sjogrens
What is the pathogenesis of myeloproliferative cell neoplasms/disorders?
Mutation in a gene coding for a tyrosine kinase: JAK2
Classify myeloproliferative disorders
CML
Myelofibrosis
Polycythemia rubra vera
Thrombocytosis
What investigations should be done into myeloproliferative disorders?
FBC Leukocyte ALK phos Bcr-abl gene arrangement Uric acid JAK2 BMT