21. Malignant Lymphoid Proliferations Flashcards
What is a haematological malignancy?
A cancer of any blood cell
How can lymphomas be classified?
Hodgkin’s vs non-hodgkin’s
How can leukaemias be classified?
Acute vs chronic
Myeloid vs lymphoid
Which cloned cell is responsible for 90% of lymphomas?
B cells
What are the manifestations of lymphomas
Painless lymphadenopathy Shortness of breath, pleural effusion Abdominal distension, ascites Fatigue B symptoms
What are B symptoms?
Fever
Night sweats
Weight loss
What is Ann Arbor Staging?
Used to stage lymphomas
- single lymph node
- one side of diaphragm
- both sides
- disseminated
Further classify non-Hodgkins lymphoma
B and T cell
Higher grade diseases have less mature cells
Further classify Hodgkins lymphoma
Classical
Non-classical
What does CD stand for?
Classification Determinant
What type of cell can be present in Hodgkins lymphoma?
Reed Sternberg cells
What markers are present from reed sternberg cells?
CD30 and CD15
What age group has the highest peak of Hodgkin’s lymphoma?
20s-30s
What lymph nodes are often enlarged in Hodgkin’s lymphoma?
Cervical
What symptoms are specific to Hodgkin’s lymphoma?
Pain after alcohol
Pruritis
