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FIP > 20. Benign Lymphoid Proliferations > Flashcards

20. Benign Lymphoid Proliferations Flashcards

1
Q

What are the lymphoid organs of the body?

A 
Lymph nodes
Spleen
Thymus
BALT
GALT
Waldeyer's ring
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2
Q

What are the causes of lymphopaenia?

A 
Acute viral infection
HIV and other immune deficiency syndromes
Steroids
Chemo
Autoimmune
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3
Q

What are the causes of lymphocytosis?

A

Viral or bacterial infection

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4
Q

Name a virus that can cause lymphocytosis

A

Mononucleosis

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5
Q

What bacteria can cause lymphocytosis?

A

TB

Whooping cough

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6
Q

What is leukaemia the cancer of?

A

Bone marrow and blood

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7
Q

What is lymphoma the cancer of?

A

Lymph nodes

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8
Q

What are the premalignant neoplastic disorders of blood?

A

Myeloproliferative and myelodysplastic syndromes

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9
Q

What lymphocyte marker is present on all lymphocytes?

A

CD45

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10
Q

What marker is specific to B cells?

A

CD20

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11
Q

What marker is specific to T cells?

A

CD3

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12
Q

What does ballerina skirting refer to?

A

Cytoplasm reaches out to touch RBCs on healthy lymphocytes

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13
Q

Why is it worrying to see one type of cell dominate a sample?

A

Could mean there is a clonal effect occurring which is likely malignant

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14
Q

What are the causes of a benign reactive node?

A 
Infection
Granulomas
Amyloid deposits
Immune reactions
Storage disorders
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15
Q

What sort of node is more likely benign?

A

Soft and tender

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16
Q

What mechanisms might happen in a benign reactive lymph node?

A

Cortex follicular hyperplasia
Sinus histiocytosis
Paracortical hyperplasia
Granulomatous reactions

17
Q

What type of cell is associated with 1. cortex follicular hyperplasia and 2. paracortical hyperplasia?

A
  1. B cells

2. T cells

18
Q

Describe the lymph node drainage

A
  1. Afferent lymphatics
  2. Sub-capsular sinuses
  3. Cortical sinuses
  4. Medullary sinuses
  5. Efferent lymphatics
19
Q

What is acute reactive lymphadenitis?

A

Secondary to a bacterial or viral infection in a drainage area

20
Q

What is chronic reactive lymphadenitis?

A

Response to chronic antigen exposure

Eg. RA, sjogrens, lupus

21
Q

What blood tests should be done to confirm a lymphadenopathy is benign?

A

FBC
CRP
LDH
viral screen

FIP (36 decks)

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