22. Pathology of nodal and bone marrow metastasis Flashcards
What drains to inguinal lymph nodes?
Lower 1/2 of GIT
Genitals
Melanoma of lower limb
Why is it unusual to get a squamous cell carcinoma on the lower limb?
More likely to get one on head, neck or lower arms as they occur where the skin is uncovered
What drains to supraclavicular lymph nodes?
Upper GIT
Bronchi
What drains to cervical lymph nodes?
Oro and naso pharynx
Head and neck carcinoma
What disease should be suspected in a 20-40 year old with an enlarged cervical node?
Hodgkin’s lymphoma
What drains to axillary lymph nodes?
Breast
How can a squamous metastasis be identified?
Keratin production
How can gland metastasis be identified?
Mucin
Tubules
What protein indicates epithelial tissue?
Cytokeratin
What protein indicates connective tissue?
Vimentin
What marker shows a neoplasm is lymphoid?
CD45
What marker shows a metastasis a melanoma originally?
S100P
Which cancers commonly metastasise to bone?
Breast Prostate Bronchus Kidney Thyroid
What general principles allow you to recognise a metastasis in bone?
Usually one spot
Stromal reaction (fibrosis, inflammation, necrosis)
Reticulin stain