Respiratory System

Question 1

name the first generation anti-histamines

Answer 1

Diphenhydramine
Dimenhydrinate
Chlorpheniramine

Question 2

name the second generation H1 blockers

Answer 2

Loratadine
Fexofenadine
Desloratadine

Question 3

name the two expectorant drugs

Answer 3

Guaifenesin

N-acetylcysteine

Question 4

MOA of Guaifenesine

Answer 4

thins the respiratory secretions but doesn’t suppress cough

Question 5

moa of n-acetylcystein

Answer 5

liquefies the mucus in COPD by disturbing disulfide bonds

also antidote to acetaminophen overdose

Question 6

MOA of dextromethorphan

Answer 6

antagonizes NMDA glutamate receptor and has mild opiod affect when used in excess

Question 7

alpha agonist that are used as nasal decongestants

Answer 7

phenylephrine and pseudophedrine

Question 8

MOA Bosnian

Answer 8

antagonist of endothelia 1 and decreases pulmonary vascular resistance

Question 9

MOA Sildenafil

Answer 9

inhibits PDE5 and prolongs vasodilation ( erectile dysfunction)

Question 10

MOA Epoprostenol and Iloprost

Answer 10

PGI2 with direct vasodilation affects on the lungs and systemic circulation
inhibit platelet

Question 11

drugs that inactivate NFK-B the transcription factor that induces the production of TNF alpha and other inflammatory agents ( first line therapy for chronic asthma)

Answer 11

Fluticasone and Budesonide

Question 12

used in allergic asthma by blocking the binding of IgE

Answer 12

Omalizumab

Question 13

causes bronchodialtion by inhibiting phosphodiesterase. Increases cAMP. Blocks the action of Adenosine

Answer 13

Theophylline

Question 14

methacholine MOA

Answer 14

M3 agonist, used in asthma test