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First Aid Pharmacology > Immune Drugs > Flashcards

Immune Drugs Flashcards

1
Q

Cyclosporine

A

Calcineurin inhibitor; binds cyclophilin. Blocks T-cell activation by preventing IL-2 transcription.

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2
Q

Tacrolimus

A

Calcineurin inhibitor; binds FK506 binding protein (FKBP).

Blocks T-cell activation by preventing IL-2 transcription.

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3
Q

Sirolimus

A

mTOR inhibitor;
binds FKBP.
Blocks T-cell activation and B-cell differentiation by preventing response to IL-2.

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4
Q

monoclonal antibodies that block IL-2R

A

Daclizumab

Basiliximab

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5
Q

Mycophenolate`

A

Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells.

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6
Q

corticosteroids

A

inhibit NF-κB. Suppress both B- and

T-cell function

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7
Q

target for ALEMTUZUMAB

A

CD 52

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8
Q

almetuzumab treats what two things

A

CLL and MS

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9
Q

Bevacizumab treats what two things

A

colorectal cancer and renal cell carcinoma

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10
Q

Cetuximab treats

A

Stage 4 colorectal cancer

head and neck cancer

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11
Q

Rituximab treats

A

CLL
non hodgkin lymphoma
RA
ITP

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12
Q

Ifliximab treats

A

IBD
RA
Ankylosing Spondylitis
Psoriasis

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13
Q

Eculizumab treats

A

Paroxysmal Nocturnal Hemoglobinuria

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14
Q

target if the RANKL receptor

A

Denosumab

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15
Q

inhibits osteoclast maturation and treats osteoporosis

A

Denosumab

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16
Q

Targets the IgE and treats allergic asthma and prevents IgE from binding to the FC region

A

Omalizumab

17
Q

treatment for neovascular age related macular degeneration

A

Bevacizumab and Ranibizumab

18
Q

RSV prophylaxis for high risk infants

A

Palivizumab

19
Q

aldesleukin

A

IL-2

renal cell carcinoma and malignant melanoma

20
Q

Epoetin Alfa

A

EPO

anemia

21
Q

Filgrastim

A

G-CSF

recovery of bone marrow

22
Q

Sargramostim

A

GM-CSF

recovery of bone marrow

23
Q

IFN-alpha

A

chronic hep B and C
malignant melanoma
Kapsoi sarcoma

24
Q

IFN -B

A

MS

25
Q

IFN-y

A

chronic granulomatous disease

26
Q

Romiplostim

Eltrombopag

A

thrombipoietin

thrombocytopenia

27
Q

oprelvekin

A

IL-11

thrombocytopenia

First Aid Pharmacology (13 decks)

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