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First Aid Pharmacology > Reproductive System > Flashcards

Reproductive System Flashcards

1
Q

Leuprolide

Moa
USE
UDE

A 
GnRH analogue ( pulsatile- agonist) ( continous- antagonist)
- prostate cancer
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2
Q

Ethanol Estradiol, DES, mestranol

Moa
USE
UDE

A
  • Estrogens: bind the estrogen receptor
  • Ovarian Failure, HYopgonadism, Hormone replacement
  • endometrial cancer risk, clear cell adenocarcinoma of vagina (DES)
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3
Q

Clomiphene

Moa
USE
UDE

A
  • antagonist of estrogen receptor, prevents the normal feedback inhibition and increases LH (stimulates ovulation)
  • treats infertility ( an ovulation)
  • hot flashes
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4
Q

Tamoxifen

Moa
USE
UDE

A
  • antagonist to strogen at the boob
  • ER/PR + breast cancer
  • endometrial cancer
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5
Q

Raloxifene

Moa
USE
UDE

A
  • antagonist to estrogen at boob and utter
  • osteoporosis and breast cancer
  • increase in thromboembolic events
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6
Q

Anastrozole, Letrozole, Exemestane

Moa
USE
UDE

A

Aromatase Inhibitors

  • inhibit the conversion of androgens to estrogen
  • ER+ breast cancer in postemenopausle women
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7
Q

Levonorgestrel, Medroxyprogesterone, Etonogestrel, Norethindrone

Moa
USE
UDE

A

Progestins

  • bind progesterone receptors, thicken the cerivcal mucous and decrease the growth of the endometrium
  • contraception
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8
Q

Mifepristone and Ulipristal

Moa
USE
UDE

A

Antiprogestins

  • competitive inhibits of progesterone receptor
  • termination of pregnancy or emergency contraception (ulipristal)
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9
Q

copper intrauterine device

Moa
USE
UDE

A

produces local inflammation that is toxic to the sperm and the scum

  • long acting reversible contraception
  • heavier and longer periods
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10
Q

terbutaline and ritodrine

Moa
USE
UDE

A

b 2 agonist that relax the uterus

- deceases contraction in women during labor

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11
Q

Danazol

Moa
USE
UDE

A
  • synthetic androgen that is a partial agonist at androgen receptor s
  • endometriosis
  • weight gain and hirtuism
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12
Q

testosterone and methyl testosterone

Moa
USE
UDE

A
  • agonist at androgen receptor
  • treats hypogonadism and develops secondary sexual characteristics
  • causes masculinization in women
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13
Q

Finasteride

Moa
USE
UDE

A
  • 5 alpha reductase inhibitor

- BPH and male pattern baldness

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14
Q

Flutamide

Moa
USE
UDE

A
  • inhibitor of androgen receptors

- prostate carcinoma

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15
Q

Ketoconazole

Moa
USE
UDE

A
  • inhibits steroid synthesis

- Polycystic Ovarian Syndrome

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16
Q

Spironolactone

Moa
USE
UDE

A
  • inhibits steroid binding

- polycystickidney disease

17
Q

tamsulosin

Moa
USE
UDE

A
  • alpha antagonist

- treats BPH ( inhibits smooth muscle contraction)

18
Q

where are alpha 1AD receptors found

A

on the prostate`

19
Q

Sildenafil, Vardenafil, Tadalafil

Moa
USE
UDE

A
  • inhibit PDE-5 and increase cGMP so erection can occur
  • erectile dysfunction
  • cyanopia ( blue tinted vision)
20
Q

minoxidil

Moa
USE
UDE

A
  • direct arteriolar vasodilator

- androgenic alopecia and severe refractory HTN

First Aid Pharmacology (13 decks)

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