Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

First Aid Pharmacology > Heme/Onc > Flashcards

Heme/Onc Flashcards

1
Q

Bivalirudin

Moa
Use
UDe

A
  • inhibits thrombin ( direct thrombin inhibitors)
  • HIT and thromboembolism
  • Bleeding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Apixaban Rivaroxiban

Moa
Use
UDe

A
  • Direct 10a inhibitors
  • prophylaxis for DVT
  • bleeding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Alteplase, Reteplase, Streptokinase,Tenecteplase

Moa
Use
UDe

A
  • thrombolytics, aid in the conversion of plasminogen into plasmin
  • MI or stroke
  • Bleeding ( contraindicated in patients who are actively bleed)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Clopidegrel
Prasugrel
Ticagrelor
Ticlopidine

Moa
Use
UDe

A

ADP receptro inhibtos

  • inhibit platelet aggregation
  • ticlopidine causes neutropenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cilostazol, Dipyridamole

Moa
Use
UDe

A
  • phosphodiesterase III inhibitors and inhibit platelets aggregation by increasing cAMP
  • Intermittent claudication
  • nausea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Abciximab, Eptifibitide, Tirofiban

Moa
Use
UDe

A

binds to the IIb/IIIa receptors so the it cannot bind to other platelets

  • unstable angina
  • bleeding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

drugs that inhibit both the G2 and S phase of the cell cycle

A

etoposide
teniposide
irinotecan
toptecan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

drugs that inhibit S phase of cell cylce

A

Antimetabolite
Cytarabine
Cladribine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Drugs that inhibit G2 phase of cell cycle

A

Bleomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Drugs that inhibit the M phase of the cell cylce

A

Pacitazel
Vinblastin
VIncristine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

cancer drug responsible for DNA strand breakage

A

Bleomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

DNA intercalates

A

Dactinomycin and Doxorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

drug that disrupts cross liking of DNA

A

cisplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

drugs the inhibit de novo purine synthesis

A

6-MC and Azathioprine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what cancer drugs are metabolized by xanthine oxidase so they both have increased toxicity in the event of giveng allopurinol

A

6-MCP and azathioprine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

cancer drug that inhibits DNA polymerase

A

cytarabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

the effects of 5 FU are enhanced with the addition of what

A

leucovorin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Bleomycin treats?

A

testicular cancer

Hodgkin lymphoma

19
Q

Dactinomycin treats

A

wilms tumor
Ewing Sarcoma
Rhabdomyosarcoma

20
Q

Doxorubicin and Daunorubicin treat?

A

solid tumors
leukemias
lymphomas

21
Q

what can Doxo/Daunorubcin cause

A

dilated cardiomyopathy

22
Q

chelating agent given to patients on Doxo/Daunorubicin so that dilated cardiomyopathy doesn’t occur

A

Dexrazoxane

23
Q

Busulfan

Moa
Use
UDe

A

Alkylating Agent

  • cross links DNA
  • CML ( ablates bone marrow before bone marrow transplant)
  • pulmonary fibrosis
24
Q

Cyclophosphamide and Ifosfamide

Moa
Use
UDe

A

Alkylating Agent

  • cross links DNA at guanine N-7
  • solid tumors, leukemia and lymphoma
  • hemorrhagic cystitis ( prevent with meson)
25
Q

Carmustine, Lomustine, Semustine, Streptozocin

Moa
Use
UDe

A

Nitrosureases (Alkylating Agent )

  • cross BBB ( cross link DNA)
  • brain tumors and GBM
  • CNS toxicity
26
Q

use for 6MCP and Azathioprine

A

prevent organ rejection
IBD
SLE

27
Q

Cladribine treats?

A

Hair cell leukemia

28
Q

Cytaravine treats

A

AML and lymphomas

29
Q

5FU treats

A

colon cancer
pancreatic cancer
basal cell carcinoma

30
Q

Methotrexate treats

A

RA
Sarcomas
Carcinomas
Ectopic pregnancy

31
Q

Paclitaxel

Moa
Use
UDe

A
  • hyper stabilize polymerized microtubule in M phase so spindle cannot break down
  • Ovarian and Breast Cancer
    myelosuppresion
32
Q

Vincristine and Vinblastine

Moa
Use
UDe

A
  • bind B tubulin and inhibit its polymerization into microtubules
  • Solid tumor, Hodgkin Lymphoma, Non Hodgkin
    neurotoxic
33
Q

Cisplatin and Carboplatin

Moa
Use
UDe

A

cross link DNA

  • testicualr, bladder,ovarian and lung cancer
  • nephrotoxic
34
Q

irinotecan and topotecan treat?

A

colon cancer
ovarian cancer
small cell lung cancer

35
Q

Hyrdroxurea treats

A

melanoma
CML
sicke cell

36
Q

Prednisone and Prednisolone

Moa
Use
UDe

A
  • alter gene expression
  • most common steroid used in chemotherapy
    cushing like symptoms and weight gain
37
Q

Bevacizumab

Moa
Use
UDe

A
  • monoclonal antibody against VEGF
  • solid tumors
    hemorrhage
38
Q

Erlotinib

Moa
Use
UDe

A
  • EGFR tyrosine kinase inhibitor
  • non small cell lung carcinoma
  • rash
39
Q

Cetuximab

Moa
Use
UDe

A
  • monoclonal against EGFR
  • stage 4 colorectal cancer
  • rash
40
Q

Imatinib

Moa
Use
UDe

A
  • tyrosine kinase inhibitor of BCR-ABL
  • CML
  • fluid retention
41
Q

Rituximab

Moa
Use
UDe

A
  • monoclonal against CD20 ( b cell neoplasms )
  • non hodgkin lymphoma
  • progressive multifocal leukoencephalopathy
42
Q

Tamoxifen and Raloxifen

Moa
Use
UDe

A
  • selective estrogen modulators
  • breast cancer, raloxifine-osteoperosis
  • tamoxifen- endometrial cancer
43
Q

Trastuzumab

Moa
Use
UDe

A
  • monoclonal against HER2
  • Her2 breast cancer
    Cardiotoxic
44
Q

Vermurafenib

Moa
Use
UDe

A
  • inhibitor of BRAF

- metastatic melanoma

First Aid Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions