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First Aid Pharmacology > Heme/Onc > Flashcards

Heme/Onc Flashcards

1
Q

Bivalirudin

Moa
Use
UDe

A
  • inhibits thrombin ( direct thrombin inhibitors)
  • HIT and thromboembolism
  • Bleeding
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2
Q

Apixaban Rivaroxiban

Moa
Use
UDe

A
  • Direct 10a inhibitors
  • prophylaxis for DVT
  • bleeding
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3
Q

Alteplase, Reteplase, Streptokinase,Tenecteplase

Moa
Use
UDe

A
  • thrombolytics, aid in the conversion of plasminogen into plasmin
  • MI or stroke
  • Bleeding ( contraindicated in patients who are actively bleed)
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4
Q

Clopidegrel
Prasugrel
Ticagrelor
Ticlopidine

Moa
Use
UDe

A

ADP receptro inhibtos

  • inhibit platelet aggregation
  • ticlopidine causes neutropenia
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5
Q

Cilostazol, Dipyridamole

Moa
Use
UDe

A
  • phosphodiesterase III inhibitors and inhibit platelets aggregation by increasing cAMP
  • Intermittent claudication
  • nausea
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6
Q

Abciximab, Eptifibitide, Tirofiban

Moa
Use
UDe

A

binds to the IIb/IIIa receptors so the it cannot bind to other platelets

  • unstable angina
  • bleeding
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7
Q

drugs that inhibit both the G2 and S phase of the cell cycle

A

etoposide
teniposide
irinotecan
toptecan

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8
Q

drugs that inhibit S phase of cell cylce

A

Antimetabolite
Cytarabine
Cladribine

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9
Q

Drugs that inhibit G2 phase of cell cycle

A

Bleomycin

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10
Q

Drugs that inhibit the M phase of the cell cylce

A

Pacitazel
Vinblastin
VIncristine

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11
Q

cancer drug responsible for DNA strand breakage

A

Bleomycin

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12
Q

DNA intercalates

A

Dactinomycin and Doxorubicin

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13
Q

drug that disrupts cross liking of DNA

A

cisplatin

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14
Q

drugs the inhibit de novo purine synthesis

A

6-MC and Azathioprine

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15
Q

what cancer drugs are metabolized by xanthine oxidase so they both have increased toxicity in the event of giveng allopurinol

A

6-MCP and azathioprine

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16
Q

cancer drug that inhibits DNA polymerase

A

cytarabine

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17
Q

the effects of 5 FU are enhanced with the addition of what

A

leucovorin

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18
Q

Bleomycin treats?

A

testicular cancer

Hodgkin lymphoma

19
Q

Dactinomycin treats

A

wilms tumor
Ewing Sarcoma
Rhabdomyosarcoma

20
Q

Doxorubicin and Daunorubicin treat?

A

solid tumors
leukemias
lymphomas

21
Q

what can Doxo/Daunorubcin cause

A

dilated cardiomyopathy

22
Q

chelating agent given to patients on Doxo/Daunorubicin so that dilated cardiomyopathy doesn’t occur

A

Dexrazoxane

23
Q

Busulfan

Moa
Use
UDe

A

Alkylating Agent

  • cross links DNA
  • CML ( ablates bone marrow before bone marrow transplant)
  • pulmonary fibrosis
24
Q

Cyclophosphamide and Ifosfamide

Moa
Use
UDe

A

Alkylating Agent

  • cross links DNA at guanine N-7
  • solid tumors, leukemia and lymphoma
  • hemorrhagic cystitis ( prevent with meson)
25
Carmustine, Lomustine, Semustine, Streptozocin Moa Use UDe
Nitrosureases (Alkylating Agent ) - cross BBB ( cross link DNA) - brain tumors and GBM - CNS toxicity
26
use for 6MCP and Azathioprine
prevent organ rejection IBD SLE
27
Cladribine treats?
Hair cell leukemia
28
Cytaravine treats
AML and lymphomas
29
5FU treats
colon cancer pancreatic cancer basal cell carcinoma
30
Methotrexate treats
RA Sarcomas Carcinomas Ectopic pregnancy
31
Paclitaxel Moa Use UDe
- hyper stabilize polymerized microtubule in M phase so spindle cannot break down - Ovarian and Breast Cancer myelosuppresion
32
Vincristine and Vinblastine Moa Use UDe
- bind B tubulin and inhibit its polymerization into microtubules - Solid tumor, Hodgkin Lymphoma, Non Hodgkin neurotoxic
33
Cisplatin and Carboplatin Moa Use UDe
cross link DNA - testicualr, bladder,ovarian and lung cancer - nephrotoxic
34
irinotecan and topotecan treat?
colon cancer ovarian cancer small cell lung cancer
35
Hyrdroxurea treats
melanoma CML sicke cell
36
Prednisone and Prednisolone Moa Use UDe
- alter gene expression - most common steroid used in chemotherapy cushing like symptoms and weight gain
37
Bevacizumab Moa Use UDe
- monoclonal antibody against VEGF - solid tumors hemorrhage
38
Erlotinib Moa Use UDe
- EGFR tyrosine kinase inhibitor - non small cell lung carcinoma - rash
39
Cetuximab Moa Use UDe
- monoclonal against EGFR - stage 4 colorectal cancer - rash
40
Imatinib Moa Use UDe
- tyrosine kinase inhibitor of BCR-ABL - CML - fluid retention
41
Rituximab Moa Use UDe
- monoclonal against CD20 ( b cell neoplasms ) - non hodgkin lymphoma - progressive multifocal leukoencephalopathy
42
Tamoxifen and Raloxifen Moa Use UDe
- selective estrogen modulators - breast cancer, raloxifine-osteoperosis - tamoxifen- endometrial cancer
43
Trastuzumab Moa Use UDe
- monoclonal against HER2 - Her2 breast cancer Cardiotoxic
44
Vermurafenib Moa Use UDe
- inhibitor of BRAF | - metastatic melanoma

First Aid Pharmacology (13 decks)

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