MSK/SKIN/CT Flashcards
Epoprostenol is an analogue to what PG
PGI2
Alprostadil is an analogue to what PG
PGE1
Dinoprostone is an analogue to what PG
PGE2
Carboprost is an analogue to what PG
PGF2
Acetaminophen
MOA
USE
UDE
- reversibly inhibits COX in CNS
- antipyretic (fever), analgesic but not anti-inflammatory
- hepatic necrosis if you OD ( antidote N-Acetylcysteine)
cytokines that are pro inflammatory that cause the upregulaiton of COX2 which usually isn’t expressed and is undetectable in tissues
IL-1 and TNF-a
Aspirin
MOA
USE
UDE
- irreversibly inhibits COX 1 and 2 by covalent acetylation and decrease synthesis of TXA2
- decreases platelet aggregation at low does, high dose: anti inflammatory
- Gastric ulcer, tinnitus Reye syndrome
Celecoxib
MOA
USE
UDE
- reversibly inhibits COX ( maintains the gastric mucosa)
- RA and Osteoarhtirits
- sulfa allergy
NSAIDS
(ketorolac and diclofenac - uncommon ones)
MOA
USE
UDE
- reversibly inhibits COX 1 and 2
- anti inflammation, anti fever
- gastric ulcer
Leflunomide
MOA
USE
UDE
- surpasses t cell proliferation ( inhibiting dihydroorotate DH)
- RA and Psoriatic Arthritis
- Teratogenic
Bisphosphanates
- ALendronate
- ibandronate
- risendronate
- zoledronate
MOA
USE
UDE
- inhibit osteoclast activity
- osteoporosis, PAget’s, osteogenesis imperfect
- esophagitis ( patients should take it with water and remain upright for at least 30 mins)
Teriparatide
MOA
USE
UDE
- PTH analogue increases osteoblast activity
- osteoporosis
- transient hypercalcemia
what is used in lymphoma and leukemia to prevent tumor lysis associated nephropathy
Allopurinol
Azathioprine and 6-MP both in creased when you give allopurinol why?
Because xanthine oxidase metabolizes these two cancer drugs and without it they ill build up in the system
the recombinant uricase that catalyzes the metabolism of uric acid to allantoin ( more water soluble product) is
pegloticase
