Respiratory Pathology up to Sp Pneumonias (AH) Flashcards
Stars mean either he said it was important in class, he emphasized it during the review or Muzzy marked it as a previous TQ. Number of starts is not indicative of anything.
What makes up the Conductive respiratory system?
nostrils, pharynx, larynx, trachea, and bronchi
What makes up the Transitional respiratory system?
bronchioles
What makes up the gas exchange system?
Pneumocytes in alveoli
What are the two types of pneumocytes and which one can regenerate?
Type I-membranous (BM)- no regeneration –> fluid into alveoli from blood vessel.
Type II- granular. Type II regenerates.
What makes up the detox system?
Goblet cells in the bronchioles are replaced by clara cells (detox similar to hepatocytes)
***What are the main routes of entry of etiological agents?
Aerogenous (infectious/non-infectious).
Hematogenous (infectious/toxins).
Direct extension (infections through trauma)
What are the main defense mech against aerogenous entry?
- Sneeze, cough, reflex bronchoconstriction.
- Mucocilliary effect: mycociliary clearance, antibodies, lysosomes, mucus.
- BALT: bronchiole associated lymphatic tissue (immunologic).
- Alveolar macrophages
What does mucocilliary defend against?
***Particles >10um, about 5% of particles 1-2um in Bronchi
**Which bacteria are resistance to alveolar macrophages?
Mycobacterium
Rhodococcus
Lysteria spp.
**Which spp. defend against blood borne agents with pulmonary intravascular macrophages?
Ruminants
Pigs
Cats
Horses
**In what spp. are hepatic and splenic macrophages key in fighting blood borne agents?
Dog
Rodent
Human
How do viruses impair pulmonary defense mechanisms?
Destruction of mucocilliary blanket
Impaired alveolar macrophage function
How do bacteria impair pulmonary defense mech?
Some live and replicate within macrophages.
Produce toxins –> direct destruction of cells
What is Rhinitis?
Inflammation of the nasal cavity
Main causes of rhinitis?
Viral Bacterial Fungal Parasites Chemicals Allergens
How is rhinitis characterized?
Nature of the exudate which varies by causative agent
What are the types of exudate associated with Rhinitis?
Serous - serum. Catarrhal - Mucous membranes. Purulent - pus. Hemorrhagic - blood. Granulomatous - granulation/ ulcers
What is the only dz of the nasal cavity and sinuses is found in bovine?
Infectious bovine rhinotracheitis (red nose)
What is the etiology of IBR?
Bovine herpes virus
What type of discharge is associated with IBR?
Serous to mucopurulent
When is IBR fatal?
2* M. hemolytica infection –> pneumonia
What are the CS of IBR? (5)
Pyrexia, anorexia, coughing. ***Serous to mucopurulent*** nasal discharge. Lacrimation and corneal opacity. Inflamed nares (red nose). Dyspnea of laryngitis develops.
Lesions of IBR?
. Hyperemia and pustules in the nasal mucosa.
- Lesions develop to ulcers and fibrinonecrotic membranes, extending to pharynx, larynx and trachea.
- Petechial to ecchymotic hemorrhages on the mucous membranes of nasal cavity and paranasal sinuses.
- Serous to serofibrinous exudate, may be blood tinged, in pharynx and trachea.
- Pharyngeal lymph nodes are swollen and hemorrhagic.
- INIBs
In addition to nasal infections what else can IBR cause?
Genital infections in breeding cattle