Respiratory (EB) Flashcards
3 routes of entry of respiratory dz etiological agents?
Aerogenous Hematogenous Direct extension
How does the body defend against airborne agent (aerogenous) (4)
Sneeze/cough/reflex bronchoconstriction
Mucocillirary effect
Bronchial associated lymphoid tissue
Alveolar defense (pulmonary alveolar macrophages)
What parts of the respiratory system are considered to be sterile
trachea, bronchi, lungs
Why size particles are effectively trapped by the mucociliary clearance? What size particles are only about 5% trapped?
> 10 um trapped
1-2 um rarely trapped»_space; INFECTIOUS AGENTS
Which bacteria are resistant to killing by macrophages? (3)
Mycobacterium, Rhodococcus, Lysteria sp.
With what test can mycobacterium bovis in a cow lung be identified?
acid fast stain
In what spp are pulmonary INTRAVASCULAR macrophages the defense against blood borne agents in the lungs?
Ruminants
Pig
Cat
Horse
In what spp are hepatic macrophages and splenic macrophages the defense against blood borne agents in the lungs?
Dog
Rodent
(Human)
How do viruses impair lung defense mechanisms? (2)
- Destruction of mucocilliary blanket
2. Impaired alveolar macrophage function
How do bacteria impair lung defense mechanisms
some live and replicate within macrophages
What toxins cause direct injury to the lung defense mechanisms (6)
Uremia Dehydration Endotoxemia Hypoxia Edema Anesthesia
Pneumocystis carinii infection causes impairment of lung defense mechanisms in which spp? (4)
Rodents
Pigs
Arabian foals
Dogs
What is inflammation of the nasal cavity?
rhinitis
What characterizes rhinitis? What does this vary with?
characterized on the nature of exudate
Varies with causative agent
Causes of infectious bovine rhinotracheitis? Other name?
bovine herpes virus
Also called red nose
What type of cattle more commonly get infectious bovine rhinotracheitis in the USA? What predisposes them for them to be fatal?
feedlot cattle
Secondary bacterial pneumonia caused by M. hemolytica is fatal
Young calves with bovine herpes virus show what CS?
Generalized dz with: Resp distress Diarrhea In-coordination Death
What respiratory clinical signs to feedlot cattle have of infectious bovine rhinotrachetitis?
coughing, nasal discharhe (serous to mucopurulent), inflamed/red nares, dyspnea
What lesions are seen in the larynx, pharynx, and trachea with IBR?
ulcers and fibronecrotic membranes
Type of exudate in the pharynx and trachea of cows with IBR?
Serous to serofibrinous. May be blood tinged
What spp get nasal granuloma aka granulomatous rhinitis? (4)
Cattle
Horses
Dogs
Cats
What are the possible etiological agents of nasal granuloma (broad) (3)
Mycotic
Blood fluke
Allergic
Mycotic organisms that cause nasal granulomas and in which spp does each cause it?
Rhinosporidium seeberi - cattle, dog, horse, cat
Cryptococcus neoformans – cats
Aspergillus – dogs
Penicillium - dogs
What happens if there is a large overgrowth of a nasal granuloma?
severe resp distress
Specific disease of the nasal cavity in sheep/goats (3)
Nasal Granuloma
Myasis
Endemic ethmoidal carcinoma
How does myasis cause nasal cavity sz in sheep/goats?
Larvae of estrus ovis (nasal bot) produce catarrhal to suppurative rhinitis
Etiology of equine viral rhinopneumonitis
Eequine herpes virus 4 and occasionally 1
Lesions of equine viral rhinopneumonitis?
Ulceration and necrosis of respiratory epithelium
Intranuclear includsions in epithelial cells
Ddx of equine viral rhinopneumonitis?
equine influenza Equine viral arteritis
Big CS of equine viral rhinopneumonitis?
sometimes edematous swelling of pharyngeal lnn
Etiology of equine influenza
type A othromyxovirus
Lesions of equine influenza
not usually seen in nasal passages.
Maybe interstitial pneumonia and pulmonary edema
Etiology of equine viral arteritis
arterivirus
Type of rhinitis caused by equine viral arteritis
serous and muco purulent rhinitis
Etiology of strangles
streptococcus equi equi
Lesions of strangles
suppurative rhinitis and lymphadenitis (mandibular and parapharyngeal)
Type of nasal discharge seen in horses with strangles
bilateral mucopurulent nasal discharge
Sequela can result from strangles? (4) for some reason he cares about strangles
- Extension of infection to paranasal sinuses and guttural pouch and internal organs
- Laryngeal hemiplegia
- Facial paralysis and horners
- Purpura hemorrhagica
Dz’s of the nasal cavity in dogs?
Transitory rhinitis
Nasal granuloma
Linguatula serrata
Allergic rhinitis
Etiology of feline virus rhinotracheitis CARES ABOUT THIS DZ A LOT DURING REVIEW
feline herpesvirus-1
Feline viral rhinotracheitis also causes what conditions?
Ulcerative keratitis
Hepatic necrosis
Abortion Still birth
Bacterial contamination in feline viral rhinotracheitis produces?
suppurative rhinitis and conjunctivitis
CS of feline viral rhinotracheitis?
Severe rhinitis
Conjunctivitis with oculonasal discharge
When and where can intranuclear inclusions be found in cats with FVR?
When: Early phase of disease
Where: Epithelium of upper resp passage
In addition to conjunctivitis and rhinitis, what other lesions are found in feline calicivirus?
ulcers of the tongue and hard palate
Primary lesions in feline calicivirus are transient, what complicates the lesions?
secondary bacteria
What is limping kitten syndrome?
an acute self-limiting arthritis cause by infection or vx with some FCV strains
What causes feline chlamydiosis? Lesions?
Chlamydyophilla felis
Lesions: Mild conjunctivitis and serous to mcopurulent rhinitis
What are the causative agents of feline respiratory dz complex? CARED ABOUT THIS IN REVIEW(5)
FCV FVR Chlamydia Mycoplasma FIP
Cause of inclusion body rhinitis in pigs
porcine cytomegalovirus (herpes virus)
What age of pigs are affected by inclusion body rhinitis? Lesions?
Up to 10 wks of age .
Lesions: necrotizing and non suppurative
Etiology of atrophic rhinitis
combo of B. bronchiseptica and P. multocida
OLDER PIGS
What causes the crusting of the skin below the medial canthus of the eye in atrophic rhinitis in pig?
obstruction of the nasal lacrimal duct
What is left of the turbinates in atrophic rhinitis?
a dense fibrous band
Nasal cavity neoplasms occur most frequently in? less in? rare in?
Most often in dogs
Less in cats and horses
Rare in other spp
Which is the most common nasal cavity neoplasia is SCC in what spp?
cats and horses
Are carcinomas or sarcomas of the nasal cavity more common?
carcinomas
In pigs, what specific dz causes swelling of the sinuses and distortion of the face?
atrophic rhinitis
Why would the exudate in the nasal passage be blood tinged? (4) (kinda general)
Tumors
Foreign body
Parasites
Fungal infections
What is bronchiectasis? What causes it?
Permanent abnormal dilation of bronchi from chronic bronchial obstruction and infection -> destruction of elastic and muscular components of airway walls
What does bronchiectasis predispose an animal to?
infection and compromised lung functions
2 types of bronchiectasis
Saccular
Cylindrical
What is the cause of saccular bronchiectasis? What spp gets it?
Local obstruction (foreign body or tumor or granuloma) Cattle, dogs, cats
What is the cause of cylindrical bronchiectasis? What spp gets it?
Sequel of chronic bronchopneumonia > usually parasitic bronchitis
Sheep, pigs, goats
Common causes of nerve damage leading to laryngeal paralysis aka roaring (5) TQ!?!?!?!
- Mycosis of guttural pouch
- Retropharyngeal abcess
- Neoplasma of cervical lymph glands
- Injury and inflammation in neck
- Empyema of guttural pouch
What causes mycosis of the guttural pouch?
aspergillus fumigatus and other aspergillus sp
Mucosa of the guttural pouch in mycosis of the guttural pouch is covered with
Fibronecrotic exudate
Located at caudodorsal aspect of the medial pouch
What causes empyema of the guttural pouch?
strangles
COPD lesions are of?
chronic bronchitis > from allergies!
In severe cases of COPD, what happens to horse lungs? TQ?!!
Incomplete obstruction with mucus of bronchioles and alveoli, causing alveolar emphysema
What is atelectasis?
empty alveoli that do not contain air
Causes of congenital atelectasis (2)
obstruction of airways Hyaline membrane dz
What spp get hyaline membrane dz?
foals and piglets
Causes of acquired atelectasis
Compressive (pneumothorax, bloat)
Obstructive (exudate, parasites, neoplasms)
What does lung tissue in atelectasis look like?
dark red, flabby, depressed below the surface of surrounding lung
What is alveolar emphysema?
excessive air in the alveoli
Causes of alveolar emphysema (2)
Pressure of inhaled air
Incompletely closed bronchioles
What do alveolar emphysema lesions look like?
raised, pale, or white, dry, easily compressed
What is interstitial emphysema?
air collects in the CT of lungs