Respiratory meds

Question 1

Beclometasone, budesonide

Answer 1

ICS- modify transcription to decrease mucosal inflammation, bronchodilation and decrease mucus

Question 2

Salbutamol, terbutaline

Answer 2

SAB-agonist- Reverses bronchoconstriction

Question 3

Salmeterol, formoterol

Answer 3

LABA- relax airway smooth muscle and increase mucus clearance by increasing cilia action

Question 4

Montelukast

Answer 4

LTRA. Blocks CysLT1= decrease mucus, oedema and bronchoconstriction

Question 5

Tiotropium

Answer 5

Selective for M3- block vagally mediated constriction

LAMA

Question 6

Theophylline

Answer 6

Adenosine receptor antagonist- decrease bronchoconstriction

Question 7

Ipratropium

Answer 7

SAMA- blockade of muscarinic cholinergic receptors. Blocking cholinergic receptors decreases the production of cyclic guanosine monophosphate (cGMP). This decrease in the lung airways will lead to decreased contraction of the smooth muscles
Some M2 also

Question 8

S/E ICS

Answer 8

Candidiasis, hoarse voice

Question 9

S/E LABA

Answer 9

Fight or flights, tachy, palpitations, increase renin, increase glycogenolysis. Decrease B Blocker effect

Question 10

S/E LTRA

Answer 10

Headache, GI, dry mouth, hyperactivity

Question 11

S/E LAMA

Answer 11

Dry eyes, retention, dry mouth

Question 12

S/E Adenosine receptor antagonist

Answer 12

Narrow therapeutic index. CPY450 inhibitors increase concentration

Question 13

S/E SAMA

Answer 13

M2 activity- increase HR, force of contractions can result in arrhythmias. Constipation