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CPT > Immunosuppressant > Flashcards

Immunosuppressant Flashcards

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1
Q

Corticosteroids

A

Prevent IL1 and 6 from macrophages, prevent T cell activation therefore depress immune response

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2
Q

Azathioprine

A

Suppress inflammatory cystokines

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3
Q

Use of azathioprine

A

SLE and vasculitis

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4
Q

Testing before azathioprine

A

TPMT highly polymorphic- if low there is increased risk of myelosuppression

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5
Q

Ciclosporin and tacrolimus

A

Calcineurin inhibitors- prevent production of IL2

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6
Q

Mycophenolate mofetil

A

Inhibits inosine monophosphate dehydrogenase and therefore inhibits B and T cell proliferation. Spares other cells

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7
Q

Use of Mycophenolate

A

Lupus

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8
Q

S/E Azathioprine

A

Myelosuppression, Malignancy, hepatitis

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9
Q

Cyclophosphamide

A

Alkalating agent, cross liks DNA so no replication. Decreased B and T cell activity.

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10
Q

Use of Cyclophosphamide

A

Lupus. solid cancers, lymphoma

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11
Q

Methotrexate

A

FOR CANCER- Competes and reversibly inhibits dihydrofolate reductase. inhibits DNA, RNA and protein synthesis during S phase.

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12
Q

Use of methotrexate

A

RA

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13
Q

Special about methotrexate

A

Weekly dosing, NSAID interaction

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14
Q

Sulfasalazine

A

Relieve pain and stiffness and fights infection by T cell inhibition and decrease chemotaxis and degranulation

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15
Q

S/E Cyclophosphomide

A

Hemorrhagic cystitis in bladder - MESNA or hydration needed

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16
Q

S/E methotrexate

A

Teratogenic, mucositis, pneumonitis, hepatitis

17
Q

S/E sulfasalazine

A

Myelosuppression, rash, abdo pain, V and N

18
Q

Infliximab

A

TNF a - decrease inflammation and angiogenesis

19
Q

Rituximab

A

CD20- B cells that are mature, causes apoptosis. Used in RA

20
Q

Omalizumab

A

Anti IgE- neutralises IgE mediated response without degranulation - used in Asthma

21
Q

Risk of infliximab

A

TB reactivation and TNF a keep it encased.

CPT (16 decks)

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