NSAIDS Flashcards
1
Q
Celecoxib
A
Cox 2 selective inhibitor
2
Q
Uses if Cox 2 selective
A
Osteo and rheumatoid arthritis
3
Q
Aspirin
A
Cox 1 and 2 inhibitor- block prostaglandin formation to decrease pain and swelling
4
Q
Why can NSAIDs exacerbate CKD
A
Decrease renal blood slow, stop afferent dilation by stopping prostaglandins
5
Q
Why do ACEi compound CKD risk with NSAIDS
A
They stop the work of AG2 on the efferent arteriole
6
Q
Whats the different effect of cox 1 and 2 on platlets
A
Cox 1 aggregation. Cox 2 inhibit aggregation
7
Q
Why does NSAIDs carry GI risks
A
Decrease mucus, HCO3, blood flow and increase acid
8
Q
Why can NSAIDS increase free plasma bound drugs
A
Displaces protein bound drugs
