Neuro drugs Flashcards
Levodopa
Increase dopamine
Co careldopa
Added decarboxylase inhibitor to decrease peripheral Dopa breakdown. Decreases dose requirements and therefore side effects.
Pramipexole, ropinirole
D receptor agonist
Rasagiline, selegiline
MAOI, enhance dopamine by decreasing breakdown, smooths out motor issues
Entacapone
COMT inhibitor, decrease peripheral breakdown of L Dopa- prolongs response to L dopa
Procyclidine
Anticholinergic- Ach has antagonistic effect on dopamine and therefore by decreasing Ach it increases dopamine effect.
Amantidine
NMDA receptor inhibitor
Pyridostigmine
Acetylcholinesterase inhibitor, enhance neuromuscular transmission by decreasing breakdown of ACh at NMJ
S/E L dopa
Decrease efficacy as decrease in receptors. Freezing, wearing off
Dopamine agonist S/E
Impulse disorder
Anticholinerigc
Drowsy, confused, does not treat bradykinesia
ACh esterase inhibitor
SSLUDGE