Neuro drugs

Question 1

Levodopa

Answer 1

Increase dopamine

Question 2

Co careldopa

Answer 2

Added decarboxylase inhibitor to decrease peripheral Dopa breakdown. Decreases dose requirements and therefore side effects.

Question 3

Pramipexole, ropinirole

Answer 3

D receptor agonist

Question 4

Rasagiline, selegiline

Answer 4

MAOI, enhance dopamine by decreasing breakdown, smooths out motor issues

Question 5

Entacapone

Answer 5

COMT inhibitor, decrease peripheral breakdown of L Dopa- prolongs response to L dopa

Question 6

Procyclidine

Answer 6

Anticholinergic- Ach has antagonistic effect on dopamine and therefore by decreasing Ach it increases dopamine effect.

Question 7

Amantidine

Answer 7

NMDA receptor inhibitor

Question 8

Pyridostigmine

Answer 8

Acetylcholinesterase inhibitor, enhance neuromuscular transmission by decreasing breakdown of ACh at NMJ

Question 9

S/E L dopa

Answer 9

Decrease efficacy as decrease in receptors. Freezing, wearing off

Question 10

Dopamine agonist S/E

Answer 10

Impulse disorder

Question 11

Anticholinerigc

Answer 11

Drowsy, confused, does not treat bradykinesia

Question 12

ACh esterase inhibitor

Answer 12

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