Opioids Flashcards
1
Q
Morphine
A
Strong agonist to mu receptors. Decrease cAMP = decrease pain
2
Q
Fentanyl
A
100 x more potent that morphine. Can be used a sedative
3
Q
S/E morphine
A
Decrease sensitivity to CO2 in respiratory centre = respiratory depression
4
Q
Codeine
A
Moderate agonist. Broken down into morphine by CYP2D6
5
Q
Issues with codeine
A
SSRI (fluox) inhibits breakdown. Variable expression dependent of race etc. Constipation.
6
Q
Buprenophine
A
Ant/agonist. Very high affinity for mu. Partial agonist
7
Q
S/E buprenophine
A
Low BP, nausea, dizziness, treat addiction, not easily reversed.
8
Q
Naloxone
A
Reversal agent. High affinity for mu, so displaces morphine.
