Repro drugs

Question 1

Oestrogen

Answer 1

Stimulates growth of breast and endometrial tissues. Stimulates production of progesterone receptors

Question 2

S/E Oestrogen

Answer 2

Water retention, Bx tender, endo, overy, breast Ca if unopposed

Question 3

Progesterone

Answer 3

Increase breast and endometrium. Maintains pregnancy, Inhibits production of oestrogen receptors

Question 4

S/E Progesterone

Answer 4

Weight gain, retention, N/V, anabolic, acne, PMS

Question 5

Testosterone

Answer 5

Stimulates male characteristics, body hair, deep voice, aggression.

Question 6

S/E testosterone

Answer 6

Acne, voice changes, aggression, decreased HDL and increase plaque

Question 7

COCP

Answer 7

Interrupt physiological, inhibit ovulation

Question 8

S/E COCP

Answer 8

VTE, CYP450 metabolised. Reduced effect with Phenytoin and St John’s wort as they are inducers

Question 9

Alendronic acid

Answer 9

Bisphosphonates- Control osteoclast activity and decrease bone turnover.

Question 10

Finesteride

Answer 10

5 alpha reductase inhibitor- stop testosterone to dihydrotestosterone so stop enlarging prostate

Question 11

Doxazosin

Answer 11

A blocker- relax bladder neck and EUS smooth muscle

Question 12

Tamoxifen

Answer 12

Selective oestrogen receptor modulator- agonist in endo and antag in breast. Causes cells to arrest in cycle.

Question 13

Clomiphene

Answer 13

Selective oestrogen receptor modulator- treat anovulation as competes with oestrogen and increases production of anterior pituitary hormones.

Question 14

MIfepristone

Answer 14

Oral anti progestational agent, functioning as a synthetic competitive inhibitor of the progesterone receptor. Terminates pregnancy. Sensitise myometrium to progesterone induced contractions